Sesquiterpene quinones from a marine sponge Hippospongia sp That inhibit maturation of starfish oocytes and induce cell cycle arrest with HepG2 cells
Sesquiterpene quinones from a marine sponge Hippospongia sp That inhibit maturation of starfish oocytes and induce cell cycle arrest with HepG2 cells
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DOI：
10.1080/13880200600883056
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发表时间：
2006-10-01
影响因子：
3.8
通讯作者：
Cai, Guoping
中科院分区：
文献类型：
--
作者：
Liu, Hongwei;Wang, Guanghui;Cai, Guoping
在帕劳采集的海绵Hippospongia sp.的生物测定引导分离导致三种倍半萜醌代谢物的分离。通过核磁共振数据分析，确定它们为伊里马醌（1）、5-表伊里马醌（2）和5-表异海绵醌（3）。化合物2和3作为混合物（约. 4：1）。评价了所有化合物对人肿瘤细胞系NCI-H460、HepG 2、SF-268、MCF-7、HeLa和HL-60的细胞毒性、对海星卵母细胞成熟的抑制作用以及对HepG 2细胞系的细胞周期阻滞。
Bioassay-guided isolation of the marine sponge Hippospongia sp. collected at Palau led to the isolation of three sesquiterpene quinone metabolites. They were determined as ilimaquinone (1), 5-epi-ilimaquinone (2), and 5-epi-isospongiaquinone (3) by NMR data analysis. Compounds 2 and 3 were obtained as a mixture (ca. 4: 1). The cytotoxicity on human tumor cell lines of NCI-H460, HepG2, SF-268, MCF-7, HeLa, and HL-60, inhibitory effects on starfish oocytes maturation, and cell cycle arrest on HepG2 cell line for all compounds were evaluated.