Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels.
Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels.
复制标题
不良童年经历（ACE）对脑源性神经营养因子（BDNF）水平影响的系统回顾和荟萃分析。
DOI：
10.1016/j.psyneuen.2023.106071
复制
发表时间：
2023
影响因子：
3.7
通讯作者：
Walsh,KyleM
中科院分区：
文献类型：
--
作者：
Vyas,Neha;Wimberly,CourtneyE;Beaman,MMakenzie;Kaplan,SamanthaJ;Rasmussen,LineJH;Wertz,Jasmin;Gifford,ElizabethJ;Walsh,KyleM
人们仍然有兴趣确定调节不良童年经历(ACE)和负面长期健康结果之间关联的调节失调的生物标志物。然而，关于ACE暴露如何调节神经生物标志物以影响ACE暴露儿童较差的健康结果，人们知之甚少。为了解决这个问题，我们对ACE暴露对脑源性神经营养因子(BDNF)水平的影响进行了系统的回顾和荟萃分析--BDNF是一种参与儿童和成人神经发生和长期记忆形成的神经生物标志物。22项研究被选为纳入系统评价，其中10项纳入荟萃分析。大多数研究包括回顾评估儿童期虐待对临床人群的影响。从10个出版物中提取样本大小、暴露于ACE的和未暴露的受试者中的BDNF蛋白水平以及标准差，以估计暴露类别之间的BDNF均值比(ROM值)。总体而言，在ACE暴露组和未暴露组之间，BDNF蛋白水平没有显著差异(ROM值：1.08；95%CI：0.93-1.26)。采样时的年龄、分析物类型(如血清、血浆、血液)和ACE暴露的类别导致研究间高度的异质性，其中一些在基于子集的分析中被最小化。这些结果支持对ACE暴露对神经生物标记物的影响的持续调查，并突出了分析物类型和样本收集时间对研究结果的潜在重要性。
There is continued interest in identifying dysregulated biomarkers that mediate associations between adverse childhood experiences (ACEs) and negative long-term health outcomes. However, little is known regarding how ACE exposure modulates neural biomarkers to influence poorer health outcomes in ACE-exposed children. To address this, we performed a systematic review and meta-analysis of the impact of ACE exposure on Brain Derived Neurotrophic Factor (BDNF) levels - a neural biomarker involved in childhood and adult neurogenesis and long-term memory formation. Twenty-two studies were selected for inclusion within the systematic review, ten of which were included in meta-analysis. Most included studies retrospectively assessed impacts of childhood maltreatment in clinical populations. Sample size, BDNF protein levels in ACE-exposed and unexposed subjects, and standard deviations were extracted from ten publications to estimate the BDNF ratio of means (ROM) across exposure categories. Overall, no significant difference was found in BDNF protein levels between ACE-exposed and unexposed groups (ROM: 1.08; 95 % CI: 0.93–1.26). Age at sampling, analyte type (e.g., sera, plasma, blood), and categories of ACE exposure contributed to high between-study heterogeneity, some of which was minimized in subset-based analyses. These results support continued investigation into the impact of ACE exposure on neural biomarkers and highlight the potential importance of analyte type and timing of sample collection on study results.