Live simian immunodeficiency virus vaccine correlate of protection: local antibody production and concentration on the path of virus entry.
Live simian immunodeficiency virus vaccine correlate of protection: local antibody production and concentration on the path of virus entry.
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DOI：
10.4049/jimmunol.1400820
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发表时间：
2014-09-15
期刊：
影响因子：
--
通讯作者：
Haase AT
中科院分区：
文献类型：
--
作者：
Li Q;Zeng M;Duan L;Voss JE;Smith AJ;Pambuccian S;Shang L;Wietgrefe S;Southern PJ;Reilly CS;Skinner PJ;Zupancic ML;Carlis JV;Piatak M Jr;Waterman D;Reeves RK;Masek-Hammerman K;Derdeyn CA;Alpert MD;Evans DT;Kohler H;Müller S;Robinson J;Lifson JD;Burton DR;Johnson RP;Haase AT
我们通过在恒河猴动物模型中确定高度有效的SIV减毒活疫苗所提供的保护的相关因素，寻求预防艾滋病毒传播给妇女的疫苗的设计原则。我们发现SIVmac239Δnef疫苗在恒河猴雌性生殖道粘膜上皮下募集浆细胞并诱导异位淋巴滤泡形成。浆细胞和异位卵泡产生与病毒包膜糖蛋白gp41三聚体反应的IgG抗体，这些抗体集中在宫颈储备上皮和阴道上皮中新生儿Fc受体（FcRn）的病毒进入途径上。这种局部抗体产生和传递系统在空间和时间上与抵抗高剂量致病性SIV阴道攻击的局部保护成熟相关。因此，设计疫苗来诱导粘膜前线抗体的产生和浓度，可能有助于开发有效的疫苗来保护妇女免受艾滋病毒-1的侵害。
We sought design principles for a vaccine to prevent HIV transmission to women by identifying correlates of protection conferred by a highly effective live attenuated SIV vaccine in the rhesus macaque animal model. We show that SIVmac239Δnef vaccination recruits plasma cells and induces ectopic lymphoid follicle formation beneath the mucosal epithelium in the rhesus macaque female reproductive tract. The plasma cells and ectopic follicles produce IgG antibodies reactive with viral envelope glycoprotein gp41 trimers, and these antibodies are concentrated on the path of virus entry by the neonatal Fc receptor (FcRn) in cervical reserve epithelium and in vaginal epithelium. This local antibody production and delivery system correlated spatially and temporally with the maturation of local protection against high dose pathogenic SIV vaginal challenge. Thus, designing vaccines to elicit production and concentration of antibodies at mucosal frontlines could aid development of an effective vaccine to protect women against HIV-1.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
5.4
作者：
Means, RE;Greenough, T;Desrosiers, RC
通讯作者：
Desrosiers, RC
影响因子：
5.4
作者：
Moore, PL;Crooks, ET;Binley, JM
通讯作者：
Binley, JM
影响因子：
6
作者：
Maidji, E;McDonagh, S;Pereira, L
通讯作者：
Pereira, L
DOI：
10.1073/pnas.1103012108
发表时间：
2011-07-05
影响因子：
11.1
作者：
Burton, Dennis R.;Hessell, Ann J.;Moore, John P.
通讯作者：
Moore, John P.