CREB: A major mediator of neuronal neurotrophin responses
CREB: A major mediator of neuronal neurotrophin responses
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DOI：
10.1016/s0896-6273(00)80395-5
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发表时间：
1997-11-01
期刊：
影响因子：
16.2
通讯作者：
Greenberg, ME
中科院分区：
文献类型：
--
作者：
Finkbeiner, S;Tavazoie, SF;Greenberg, ME
Neurotrophins regulate neuronal survival, differentiation, and synaptic function. To understand how neurotrophins elicit such diverse responses, we elucidated signaling pathways by which brain-derived neurotrophic factor (BDNF) activates gene expression in cultured neurons and hippocampal slices. We found, unexpectedly, that the transcription factor cyclic AMP response element-binding protein (CREB) is an important regulator of BDNF-induced gene expression. Exposure of neurons to BDNF stimulates CREB phosphorylation and activation via at least two signaling pathways: by a calcium/calmodulin-dependent kinase IV (CaMKIV)-regulated pathway that is activated by the release of intracellular calcium and by a Ras-dependent pathway. These findings reveal a previously unrecognized, CaMK-dependent mechanism by which neurotrophins activate CREB and suggest that CREB plays a central role in mediating neurotrophin responses in neurons.
