Fetal mesenchymal stem cells: isolation, properties and potential use in perinatology and regenerative medicine
Fetal mesenchymal stem cells: isolation, properties and potential use in perinatology and regenerative medicine
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DOI：
10.1111/j.1471-0528.2008.02005.x
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发表时间：
2009-01-01
影响因子：
5.8
通讯作者：
Deprest, J.
中科院分区：
文献类型：
--
作者：
Gucciardo, L.;Lories, R.;Deprest, J.
胎儿是非胚胎干细胞（SC）的来源，在围产期医学中具有潜在的应用。与成人组织来源的SC相比，来自胎盘、胎膜、羊水或胎儿组织的SC在数量、扩增潜力和分化能力上更高。虽然一些障碍使SC生物学与临床应用保持距离，但已证明使用（同源）SC用于先天性出生缺陷胎儿的组织工程的可行性。此外，其他病理学可能受益于SC技术。
The fetus is a source of nonembryonic stem cells (SC), with potential applications in perinatal medicine. Cells derived from the placenta, membranes, amniotic fluid or fetal tissues are higher in number, expansion potential and differentiation abilities compared with SC from adult tissues. Although some obstacles keep SC biology at distance from clinical application, the feasibility of using (homologous) SC for tissue engineering for the fetus with a congenital birth defect has been demonstrated. Also, other pathologies may benefit from SC technology.