Smooth pursuit eye movements in patients with macular degeneration.
Smooth pursuit eye movements in patients with macular degeneration.
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DOI：
10.1167/16.3.1
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发表时间：
2016
影响因子：
1.8
通讯作者：
Verghese P
中科院分区：
文献类型：
--
作者：
Shanidze N;Fusco G;Potapchuk E;Heinen S;Verghese P
目前，还没有针对黄斑变性（MD）个体的平滑追踪（一种归因于中央凹的行为）的定量研究。我们假设 MD 患者的追踪取决于暗点和目标轨迹的相对位置。我们用扫描激光检眼镜（SLO）测试了这一假设，它可以直接观察受损视网膜上的目标。对 11 名不同程度 MD 的个体进行单眼微视野测量和眼球运动评估。观察员被要求目视跟踪一个 1.7° 的目标，该目标以 5°/s–6°/s 的速度沿八个径向方向之一移动。与我们的假设一致，追踪指标取决于目标是否移入或移出暗点。随着目标航向方向暗点范围的增加，追踪增益降低 (p = 0.017)。当沿目标轨迹（在起始方向或航向方向，p < 0.001）存在暗点时，延迟较高。此外，对视网膜位置的分析表明，近 50% 的时间目标落在注视点上。结果表明，MD患者能够平滑地追踪眼球运动，但受到目标轨迹和暗点特征的限制。
Currently, there are no quantitative studies of smooth pursuit, a behavior attributed to the fovea, in individuals with macular degeneration (MD). We hypothesize that pursuit in MD patients depends on the relative positions of the scotoma and target trajectory. We tested this hypothesis with a scanning laser ophthalmoscope (SLO), which allows for direct visualization of the target on the damaged retina. Monocular microperimetry and eye movements were assessed in eleven individuals with differing degrees of MD. Observers were asked to visually track a 1.7° target that moved in one of eight radial directions at 5°/s–6°/s. Consistent with our hypothesis, pursuit metrics depended on whether the target moved into or out of scotoma. Pursuit gains decreased with increasing scotoma extent in the target's heading direction (p = 0.017). Latencies were higher when the scotoma was present along the target trajectory (in either starting or heading directions, p < 0.001). Furthermore, an analysis of retinal position shows that targets fell on the fixational locus nearly 50% of the time. The results suggest that MD patients are capable of smooth pursuit eye movements, but are limited by target trajectory and scotoma characteristics.