Mouse models of colorectal cancer as preclinical models.
Mouse models of colorectal cancer as preclinical models.
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DOI：
10.1002/bies.201500032
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发表时间：
2015-08
期刊：
影响因子：
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通讯作者：
Adams DJ
中科院分区：
文献类型：
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作者：
McIntyre RE;Buczacki SJ;Arends MJ;Adams DJ
在这篇综述中，我们讨论了小鼠模型在结直肠癌新治疗靶点的鉴定和临床前验证以及早期疾病生物标志物的研究中的应用。结直肠癌的大规模基因组、转录组和表观基因组分析已经鉴定出许多候选基因，这些基因对肿瘤发生的直接贡献尚未确定;我们讨论了基于跨物种比较组学的方法对这个问题的实用性。我们强调了使用小鼠建模晚期疾病的最新进展，并讨论了小鼠模型可以更好地概括人类癌症的复杂性，以解决手术切除后的治疗抗性和复发问题的方法。
In this review, we discuss the application of mouse models to the identification and pre‐clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large‐scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross‐species comparative ‘omics‐based approaches to this problem. We highlight recent progress in modelling late‐stage disease using mice, and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection.