Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals.
Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals.
复制标题
DOI：
10.1016/j.chemosphere.2003.09.031
复制
发表时间：
2004-03
期刊：
影响因子：
8.8
通讯作者：
Zhifen Lin;Jianwei Du;K. Yin;Lian-Sheng Wang;Hongxia Yu
中科院分区：
文献类型：
--
作者：
Zhifen Lin;Jianwei Du;K. Yin;Lian-Sheng Wang;Hongxia Yu
根据单个化学物质的毒性机理，分别揭示了非极性麻醉性化学混合物、极性麻醉性化学混合物和反应性化学混合物的浓度加成毒性机理。对于非极性麻醉化学混合物，测定了单个化学物质从水到生物相的分配，结果表明它们的浓度相加效应是由于单个化学物质之间没有竞争性分配。对于极性麻醉化学混合物，它们的毒性是由两个因素（总基线毒性和单个化学品的氢键供体活性）造成的，这两个因素中的任何一个的浓度相加效应导致了它们的浓度相加毒性。此外，还深入讨论了活性化学物质与生物大分子的相互作用。结果表明，这些相互作用的净效应为零，正是这种零净效应导致了反应化学混合物的浓度增加毒性机制。
According to the toxicity mechanism of the individual chemicals, the concentration addition toxicity mechanism is revealed for nonpolar-narcotic-chemical mixtures, polar-narcotic-chemical mixtures and reactive-chemical mixtures, respectively. For nonpolar-narcotic-chemical mixtures, the partitioning of individual chemicals from water to biophase was determined, and the result shows that their concentration additive effect results from no competitive partitioning among individual chemicals. For polar-narcotic-chemical mixtures, their toxicity are contributed by two factors (the total baseline toxicity and the hydrogen bond donor activity of individual chemicals), and it is the concentration additive effect for either of these two factors that leads to their concentration addition toxicity. In addition, the interactions between the reactive chemicals and the biological macromolecules are discussed thoroughly. The results suggest that the net effect of these interactions is zero, and it is this zero net effect that leads to the concentration addition toxicity mechanism for reactive-chemical mixtures.