Metabolic regulation of hepatic gene expression.
Metabolic regulation of hepatic gene expression.
复制标题
肝基因表达的代谢调节。
DOI：
10.1042/bst0240364
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发表时间：
1996
影响因子：
3.9
通讯作者：
Shih,HM
中科院分区：
文献类型：
--
作者：
Towle,HC;Kaytor,EN;Shih,HM
哺乳动物的肝脏在处理摄入的营养物质方面起着关键作用。高碳水化合物低脂肪的饮食会诱导肝脏中一组基因的表达。这些基因编码葡萄糖转化为三酰基甘油的关键酶（图1）。碳水化合物喂养诱导的“脂肪生成”酶包括糖酵解酶，如丙酮酸激酶，脂肪酸合成酶，如乙酰辅酶a羧化酶，以及三酰基甘油形成酶，如甘油-3-磷酸酰基转移酶。在所有情况下，酶产生的诱导是由于相应mRNA水平的增加。在一些情况下，但不是全部，转录是反应-
The mammalian liver plays a key role in dealing with ingested nutrients. Feeding of a diet high in simple carbohydrates and low in fats induces the expression of a set of genes in the liver. These genes encode key enzymes in the conversion of glucose to triacylglycerols (Figure 1).‘Lipogenic’enzymes that have been shown to be induced by carbohydrate feeding include enzymes of glycolysis, such as pyruvate kinase, enzymes of fatty acid synthesis, such as acetyl-CoA carboxylase, and enzymes of triacylglycerol formation, such as glycerol-3-phosphate acyltransferase. In all cases, the induction of enzyme production is due to increased levels of the corresponding mRNA. In several cases, but not all, transcription is respon-