TOPICAL OR SYSTEMIC 16,16 DM PROSTAGLANDIN-E2 OR WR-2721 (WR-1065) PROTECTS MICE FROM ALOPECIA AFTER FRACTIONATED-IRRADIATION
TOPICAL OR SYSTEMIC 16,16 DM PROSTAGLANDIN-E2 OR WR-2721 (WR-1065) PROTECTS MICE FROM ALOPECIA AFTER FRACTIONATED-IRRADIATION
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DOI：
10.1080/09553009214551291
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发表时间：
1992-04-01
影响因子：
2.6
通讯作者：
MALKINSON, FD
中科院分区：
文献类型：
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作者：
GENG, L;HANSON, WR;MALKINSON, FD
我们以前在小鼠中的研究表明，全身或局部16，16 dm PGE 2可防止单剂量辐射诱导的脱发。我们现在已经研究了前列腺素，或WR-2721，对不同剂量和时间表的分次辐射产生的小鼠脱发的保护作用。在从B6 D2 F1小鼠的大腿上拔下毛发后的第1 - 8天，每组6只动物每天接受4.0或4.5戈伊照射，持续5天; 2.5、3.5、4.5或5.5戈伊照射，持续10天;或2戈伊照射，持续15天。在照射前1小时，每只小鼠通过颈部皮下注射或局部施用接受10 μ g 16，16 dmPGE 2，通过注射接受8 mg WR-2721，或通过局部施用接受0.3mg WR-1065。三周后，从切除的皮肤样本中记录再生毛发的计数。对于所使用的辐射防护剂，与仅受辐射的对照部位相比，各辐射组中的毛发再生增加了25-100%。在一些研究中，系统地提供了辐射防护剂，WR-2721提供的辐射防护略高于16，16 dm PGE 2。在局部应用研究中，这两种化合物的辐射防护作用基本相同。由于全身和局部应用的试剂测试增强辐射后的头发再生，我们得出结论，这些化合物的临床使用可能会提供一些保护毛囊，也许其他组织，躺在放射治疗领域。
Our previous studies in mice demonstrated that systemic or topical 16,16 dm PGE2 protected against single dose radiation-induced hair loss. We have now investigated prostaglandin, or WR-2721, protection against murine alopecia produced by varying doses and schedules of fractionated radiation. On days one to eight after hair was plucked from the thighs of B6D2F1 mice, groups of 6 animals each were given daily exposures of 4.0 or 4.5 Gy for 5 days; 2.5, 3.5, 4.5 or 5.5 Gy for 10 days; or 2 Gy for 15 days. One hour before irradiation each mouse received 10-mu-g 16,16 dm PGE2, either by subcutaneous injection into the neck or topical application, 8 mg WR-2721 by injection, or 0.3 mg WR- 1 065 by topical application. Three weeks later counts of regrowing hairs were recorded from excised skin samples. For the radioprotectors used, hair regrowth was increased 25-100% in the various radiation groups in comparison to irradiated-only control sites. In some studies with the radioprotectors given systematically, WR-2721 afforded slightly greater radioprotection than 16,16 dm PGE2. The two compounds were essentially equally radioprotective in the topical application studies. Since both systemic and topical applications of the agents tested enhanced hair regrowth following radiation, we conclude that clinical use of these compounds may provide some protection of hair follicles, and perhaps other tissues, lying within a radiation therapy field.