SEVERITY OF TOURETTES-SYNDROME IN ONE LARGE KINDRED - IMPLICATION FOR DETERMINATION OF DISEASE PREVALENCE RATE
SEVERITY OF TOURETTES-SYNDROME IN ONE LARGE KINDRED - IMPLICATION FOR DETERMINATION OF DISEASE PREVALENCE RATE
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DOI：
10.1001/archneur.1987.00520150024013
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发表时间：
1987-03-01
影响因子：
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通讯作者：
KIDD, KK
中科院分区：
文献类型：
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作者：
KURLAN, R;BEHR, J;KIDD, KK
Tourette综合征（TS）的准确患病率尚未确定。为了评估疾病的严重程度，在确定患病率的偏差的一个潜在来源，我们进行了标准化的问卷调查和检查，以显示明显的常染色体显性遗传的运动和发声抽搐（TS）或慢性运动抽搐（CMT）的大型门诺派亲属的159名成员。54名家庭成员被诊断为明确或可能的TS或CMT。在这54例受试者中，30%（n = 16）的受试者不知道检查者发现的抽搐，只有18.5%（n = 10）的受试者寻求过医疗护理。我们的研究结果表明，大多数TS和CMT病例都是轻度的，不会引起医疗注意。这些抽动障碍可能比人们普遍认识到的要普遍得多。
An accurate prevalence rate for Tourette''s syndrome (TS) has not been established. To assess severity of illness, a potential source of bias in determining prevalence rate, we administered standardized questionnaires and examinations to 159 members of a large Mennonite kindred showing apparent autosomal dominant transmission of motor and vocal tics (TS) or chronic motor tics (CMTs). Fifty-four family members were diagnosed as having definite or probable TS or CMTs. For these 54 subjects, 30% (n = 16) were unaware of tics noted by the examiners and only 18.5% (n = 10) had sought medical care. Our findings suggest that most cases of TS and CMTs are mild and do not come to medical attention. These tic disorders are probably much more prevalent thant generally appreciated.