Neuroprotective function of microglia in the developing brain.
Neuroprotective function of microglia in the developing brain.
复制标题
DOI：
10.1042/ns20200024
复制
发表时间：
2021-04
影响因子：
--
通讯作者：
Yamashita T
中科院分区：
文献类型：
--
作者：
Fujita Y;Yamashita T
小胶质细胞是中枢神经系统的常驻免疫细胞，对免疫过程很重要。除了在病理条件下的经典作用外，这些细胞还与神经元动态相互作用，并在生理条件下影响其结构和功能。最近的证据表明，它们在健康的大脑内稳态中的作用，包括神经发生，细胞存活，突触成熟和消除的调节，特别是在发育中的大脑中。本文就小胶质细胞在脑发育中的作用及其神经保护功能的研究进展作一综述。我们还将讨论小胶质细胞功能障碍如何导致脑功能受损，从而促进疾病的发展。
Microglia are the resident immune cells of the central nervous system and are important for immune processes. Besides their classical roles in pathological conditions, these cells also dynamically interact with neurons and influence their structure and function in physiological conditions. Recent evidence revealed their role in healthy brain homeostasis, including the regulation of neurogenesis, cell survival, and synapse maturation and elimination, especially in the developing brain. In this review, we summarize the current state of knowledge on microglia in brain development, with a focus on their neuroprotective function. We will also discuss how microglial dysfunction may lead to the impairment of brain function, thereby contributing to disease development.