Near-infrared spectroscopy as an alternative to the Wada test for language mapping in children, adults and special populations
Near-infrared spectroscopy as an alternative to the Wada test for language mapping in children, adults and special populations
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DOI：
10.1684/epd.2007.0118
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发表时间：
2007-09-01
影响因子：
2.3
通讯作者：
Lassonde, Maryse
中科院分区：
文献类型：
--
作者：
Gallagher, Anne;Theriault, Martin;Lassonde, Maryse
颈内动脉异巴比妥钠试验(IAT)是目前应用最广泛的癫痫患者术前语言偏侧化评估方法。然而，除了具有侵入性，这项技术不适用于幼儿或出现智力障碍和/或语言障碍的患者。功能磁共振成像(FMRI)作为一种非侵入性的替代方法越来越多地被使用。同样，这种方法更难用于幼儿，特别是多动症儿童，因为他们在数据采集过程中必须保持不动。本研究的目的是确定近红外光谱(NIRS)能否作为一种替代技术来研究儿童和特殊人群的语言偏侧化。与WADA测试不同，NIRS是非侵入性的，对运动伪影的耐受性比fMRI更强。在本研究中，采集了四名癫痫儿童、一名12岁患有广泛性发育障碍的男孩和一名3岁的健康儿童，以及三名健康成年人和两名癫痫患者的近红外光谱数据，同时进行了语言流利性任务和对照任务。在适用的情况下，将结果与受试者的fMRI和/或IAT结果进行比较。所有参与者，包括两名非癫痫儿童，都获得了清晰的语言偏侧性，NIRS结果与fMRI和[AT]结果相匹配。这些结果，如果可以在更大的样本中复制，是令人鼓舞的，并表明NIRS有潜力成为IAT和fMRI的一种可行的、非侵入性的替代方法，用于确定无法接受更具侵入性技术的儿童和临床人群的言语偏侧化。
The intracarotid amobarbital test (IAT) is the most widely used procedure for pre-surgical evaluation of language lateralization in epileptic patients. However, apart from being invasive, this technique is not applicable in young children or patients who present mental retardation and/or language deficits. Functional magnetic resonance imaging (fMRI) is increasingly employed as a non-invasive alternative. Again, this method is more difficult to use with young children, especially hyperactive ones, since they have to remain motionless during data acquisition. The aim of this study was to determine whether near-infrared spectroscopy (NIRS) can be used as an alternative technique to investigate language lateralization in children and special populations. Unlike Wada test, NIRS is non-invasive, and it is more tolerant to movement artefacts than fMRI. In the present study, NIRS data were acquired in four epileptic children, a 12-year-old boy with pervasive developmental disorder and a 3-year-old, healthy child, as well as three healthy and two epileptic adults, while they performed a verbal fluency task and a control task. When applicable, the results were compared to the subjects' fMRI and/or IAT findings. Clear laterality of speech was obtained in all participants, including the two non-epileptic children, and NIRS results matched fMRI and [AT findings. These results, if replicable in larger samples, are encouraging and suggest that NIRS has the potential to become a viable, non-invasive alternative to IAT and fMRI in the determination of speech lateralization in children and clinical populations that cannot be submitted to more invasive techniques.