RAT MIDDLE CEREBRAL-ARTERY OCCLUSION USING AN INTRALUMINAL THREAD TECHNIQUE
RAT MIDDLE CEREBRAL-ARTERY OCCLUSION USING AN INTRALUMINAL THREAD TECHNIQUE
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DOI：
10.1007/bf01403007
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发表时间：
1991-01-01
影响因子：
2.4
通讯作者：
FUKASAWA, H
中科院分区：
文献类型：
--
作者：
KAWAMURA, S;YASUI, N;FUKASAWA, H
对先前在大鼠中产生脑缺血的方法进行了修改（Koizumi等人，Longa等人），描述了使用管腔内螺纹技术。 通过将简单的3-0尼龙线（直径0.20-0.249 mm）引入颈部的颈内动脉来闭塞大脑中动脉。 实验证明，该方法可获得与人类脑卒中相似的可重复的局灶性脑缺血模型，因此，该模型简单、相对无创，适用于缺血性脑卒中的病理生理学研究和潜在治疗方法的检测。
A modification of the previous methods of producing cerebral ischaemia in rats (Koizumi et al., Longa et al.), using an intraluminal thread technique, is described. The middle cerebral artery is occluded by introducing a simple 3-0 nylon thread (0.20-0.249 mm in diameter) through the internal carotid artery in the neck. It has been proven that with this method reproducible focal cerebral ischaemia can be achieved which resembles human stroke.Therefore this simple and relatively non-invasive model is suitable for the pathophysiological investigation of ischaemic stroke and the testing of potential therapies.