Changes of cerebral blood flow, oxygenation, and oxidative metabolism during graded motor activation
Changes of cerebral blood flow, oxygenation, and oxidative metabolism during graded motor activation
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DOI：
10.1006/nimg.2001.0916
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发表时间：
2002-01-01
期刊：
影响因子：
5.7
通讯作者：
Moseley, ME
中科院分区：
文献类型：
--
作者：
Kastrup, A;Krüger, G;Moseley, ME
In the present studies fMRI and a hypercapnic calibration procedure were used to monitor simultaneous changes in cerebral blood flow (CBF), cerebral blood oxygenation, and cerebral metabolic rate of oxygen (CMRO2) during activation in the sensorimotor cortex. In the first set of experiments seven volunteers performed bilateral, self-paced finger tapping and in the second set of experiments six volunteers performed bilateral finger tapping with six different frequencies (0.5-3 Hz). During the latter task relative CBF and BOLD signal intensity changes varied linearly as a function of stimulus frequency. In good agreement with recent PET and fMRI data increases in CMRO2 were smaller than the corresponding changes in CBF during self-paced finger tapping and at all levels of graded motor activation. At a single level of activation and during graded activation there was a positive linear relationship between CBF and CMRO2 with ratios of approximately 3:1. Comparable proportionality constants have been found in the visual cortex and primary sensory cortex, indicating similarities between the relationship of CBF and CMRO2 in various cortical regions. (C) 2002 Elsevier Science.
