The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-α converting enzyme (TACE)
The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-α converting enzyme (TACE)
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DOI：
10.1359/jbmr.2004.19.1.147
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发表时间：
2004-01-01
影响因子：
6.2
通讯作者：
Zannettino, ACW
中科院分区：
文献类型：
--
作者：
Pan, BQ;Farrugia, AN;Zannettino, ACW
双膦酸盐被用来防止破骨细胞介导的骨丢失。唑来膦酸通过增加OPG蛋白分泌和降低跨膜RANKL表达间接抑制破骨细胞成熟。RANKL跨膜表达降低可能与RANKL脱落酶TACE上调有关。
Bisphosphonates are used to prevent osteoclast-mediated bone loss. Zoledronic acid inhibits osteoclast maturation indirectly by increasing OPG protein secretion and decreasing transmembrane RANKL expression in human osteoblasts. The decreased transmembrane RANKL expression seems to be related to the upregulation of the RANKL sheddase, TACE.