ELECTRICAL BREAKDOWN OF BIOMOLECULAR LIPID-MEMBRANES AS AN ELECTROMECHANICAL INSTABILITY
ELECTRICAL BREAKDOWN OF BIOMOLECULAR LIPID-MEMBRANES AS AN ELECTROMECHANICAL INSTABILITY
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DOI：
10.1016/s0006-3495(73)86017-5
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发表时间：
1973-01-01
影响因子：
3.4
通讯作者：
CROWLEY, JM
中科院分区：
文献类型：
--
作者：
CROWLEY, JM
双分子脂质膜（BLM）被建模为一个散装的弹性层受到压缩电力所造成的电压。对该模型的分析表明，当电应力超过临界值时，就会产生压缩不稳定性。这种不稳定性往往会粉碎的膜，从而破裂it.The预测的击穿电压，与测量值相比，磷脂酰胆碱和胆固醇，显示公平的协议，考虑到弹性参数估计的不确定性。
The bimolecular lipid membrane (BLM) is modeled as a bulk elastic layer subject to a compressive electric force caused by applied voltages. Analysis of this model shows that a compressive instability develops when the electric stress exceeds a critical value. This instability tends to crush the film and thus rupture it. The predicted breakdown voltage, when compared with measured values for phosphatidylcholine and cholesterol, shows fair agreement, considering the uncertainty in the estimate of elastic parameters.