Mitochondrial DNA, aconitase 'wraps' it up.
Mitochondrial DNA, aconitase 'wraps' it up.
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DOI：
10.1016/j.tibs.2005.04.007
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发表时间：
2005-06
影响因子：
13.8
通讯作者：
G. Shadel
中科院分区：
文献类型：
--
作者：
G. Shadel
线粒体是许多基本生化反应的场所，其中一个重要的子集需要在线粒体DNA（mtDNA）中编码的蛋白质。线粒体DNA是如何响应不断变化的细胞需求而调节的，这在很大程度上是未知的。最近的一项研究表明，线粒体TCA循环酶乌头酸酶与称为类核的蛋白质-mtDNA复合物有关。在这种新的背景下，顺乌头酸酶的功能，以稳定线粒体DNA，可能是通过可逆地重塑类核直接影响线粒体基因表达的细胞代谢的变化。
Mitochondria are the sites of many essential biochemical reactions, an important subset of which require proteins encoded in the mitochondrial DNA (mtDNA). How mtDNA is regulated in response to changing cellular demands is largely unknown. A recent study documents that the mitochondrial TCA-cycle enzyme aconitase is associated with protein–mtDNA complexes called nucleoids. In this novel context, aconitase functions to stabilize mtDNA, perhaps by reversibly remodeling nucleoids to directly influence mitochondrial gene expression in response to changing cellular metabolism.