Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome
Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome
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DOI：
10.1530/eje-14-1108
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发表时间：
2015-05-01
影响因子：
5.8
通讯作者：
Andersen, Marianne
中科院分区：
文献类型：
--
作者：
Glintborg, Dorte;Rubin, Katrine Hass;Andersen, Marianne
目的：多囊卵巢综合征（PCOS）患者中2型糖尿病的患病率增加，但其他疾病的患病率尚不清楚。我们的目的是调查发病率和药物处方在PCOS.Design：一个国家注册为基础的study.Methods：PCOS患者（PCOS丹麦和嵌入式队列; PCOS欧登塞大学医院（OUH））和一个对照人群。对1217例绝经前PCOS患者进行临床和生化检查。多囊卵巢综合征丹麦（n= 19199）包括丹麦国家患者登记册中的多囊卵巢综合征妇女。三个年龄匹配的对照包括每例患者（n=57 483）。主要结果的措施：诊断代码和填写prescriptions.Results：PCOS丹麦组和对照组的平均（范围）年龄为30.6（12-60）岁。与对照组相比，丹麦的PCOS患者具有较高的Charlson指数、较高的糖尿病、血脂异常和高血压患病率。PCOS与中风和血栓形成的风险增加两倍相关，而其他心血管疾病的风险并未增加。甲状腺疾病、哮喘、偏头痛和抑郁症在多囊卵巢综合征丹麦组比对照组更常见，而骨折更罕见。与对照组相比，PCOS患者的不孕症增加，但PCOS患者的平均出生人数更高。PCOS患者在所有诊断领域的药物处方均显著高于对照组。在多囊卵巢综合征，多囊卵巢（PCO）和月经不规律与更不利的代谢风险，但个人鹿特丹标准与心脏代谢diagnosis.Conclusion：心脏代谢和精神疾病的发病率显着增加，在丹麦人口与多囊卵巢综合征。内科疾病在年轻的PCOS患者中也很常见。
Objective: The prevalence of type 2 diabetes is increased in polycystic ovary syndrome (PCOS), but the prevalence of other diseases is not clarified. We aimed to investigate morbidity and medicine prescriptions in PCOS.Design: A National Register-based study.Methods: Patients with PCOS (PCOS Denmark and an embedded cohort; PCOS Odense University Hospital (OUH)) and one control population. Premenopausal women with PCOS underwent clinical and biochemical examination (PCOS OUH, n=1217). PCOS Denmark (n=19 199) included women with PCOS in the Danish National Patient Register. Three age-matched controls were included per patient (n=57 483).Main outcome measures: Diagnosis codes and filled prescriptions.Results: The mean (range) age of the PCOS Denmark group and controls was 30.6 (12-60) years. Patients in PCOS Denmark had higher Charlson index, higher prevalence of diabetes, dyslipidemia, and hypertension than controls. PCOS was associated with a two times increased risk of stroke and thrombosis, whereas the risk of other cardiovascular diseases was not increased. Thyroid disease, asthma, migraine, and depression were more prevalent in PCOS Denmark vs controls, whereas fractures were rarer. Infertility was increased in patients compared with controls, but the mean number of births was higher in PCOS. Medicine prescriptions within all diagnosis areas were significantly higher in PCOS patients than in controls. In PCOS OUH, polycystic ovaries (PCO) and irregular menses were associated with a more adverse metabolic risk profile, but individual Rotterdam criteria were not associated with cardiometabolic diagnoses.Conclusion: Cardiometabolic and psychiatric morbidity were significantly increased in a Danish population with PCOS. Medical diseases are frequent also in young patients with PCOS.