Molecular and cellular permeability control at the blood-brain barrier
Molecular and cellular permeability control at the blood-brain barrier
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DOI：
10.1016/s0165-0173(01)00102-3
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发表时间：
2001-10-01
影响因子：
--
通讯作者：
Frei, K
中科院分区：
文献类型：
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作者：
Gloor, SM;Wachtel, M;Frei, K
血脑屏障（BBB）由脑毛细血管内皮细胞形成。这些细胞至少有三种特性将它们与外周对应物区分开来：（1）渗透性极低的紧密连接（TJ），（2）液相内吞速率低;（3）特异性转运和载体分子。结合起来。这些特征限制了离子、蛋白质和其它物质进入中枢神经系统（CNS）环境的非特异性通量。这种限制可以保护神经元免受血液中有害成分波动的影响，并允许吸收必需分子。BBB的破坏与多种中枢神经系统疾病相关，并导致病情恶化。因此，BBB的恢复是CNS疾病治疗期间的一种策略。它的成功取决于对BBB功能的结构和功能原理的精确了解。在这篇综述中，我们试图总结目前的知识TJ，包括从非神经元系统获得的信息，并描述选定的机制参与渗透性调节。(C)2001年，爱思唯尔科学。All rights reserved.
The blood-brain barrier (BBB) is formed by brain capillary endothelial cells. These cells have at least three properties which distinguish them from their peripheral counterparts: (1) tight junctions (TJs) of extremely low permeability, (2) low rates of fluid-phase endocytosis; (3) specific transport and carrier molecules. In combination. these features restrict the nonspecific flux of ions, proteins, and other substances into the central nervous system (CNS) environment. The restriction protects neurons from harmful compositional fluctuations occurring in the blood and allows uptake of essential molecules. Breakdown of the BBB is associated with a variety of CNS disorders and results in aggravation of the condition. Restoration of the BBB is thus one strategy during therapy of CNS diseases. Its success depends on a precise knowledge of the structural and functional principles underlying BBB functionality. In this review, we have tried to summarise the current knowledge of TJs, including information gained from non-neuronal systems, and describe selected mechanisms involved in permeability regulation. (C) 2001 Elsevier Science BY. All rights reserved.