Fibrinolytic markers and neurologic outcome in traumatic brain injury
Fibrinolytic markers and neurologic outcome in traumatic brain injury
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DOI：
10.4103/0028-3886.28106
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发表时间：
2006-12-01
期刊：
影响因子：
2.7
通讯作者：
Bodur, Said
中科院分区：
文献类型：
--
作者：
Bayir, Aysegul;Kalkan, Erdal;Bodur, Said
目的：确定纤溶标志物作为孤立性头部创伤患者早期预后指标的有效性。材料与方法：本研究纳入了62名连续患者（26名女性和36名男性;平均年龄61岁，范围2-76岁），这些患者在创伤的前3小时内出现孤立性头部创伤。观察两组患者的格拉斯哥昏迷评分（GCS）、血小板计数（Plt）、凝血酶原时间（PT）、部分凝血活酶时间（PTT）、纤维蛋白原、纤维蛋白降解产物（FDP）和D-二聚体水平。头部计算机断层扫描（CT）结果分为脑水肿，线性骨折，凹陷性骨折，挫伤和出血。将血小板计数、PT、PTT、纤维蛋白原、FDP、D-二聚体水平和CT结果与第一周的GCS和死亡率进行比较。统计学显著性被接受为P
Aims: To determine the usefulness of fibrinolytic markers as early prognostic indicators in patients with isolated head trauma. Materials and Methods: Sixty-two consecutive patients (26 women and 36 men; mean age 61 years, range 2-76 years) with isolated head trauma seen within the first three hours of the trauma were included in the study. The Glasgow Coma score (GCS), platelet counts (Plt), prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen, fibrin degradation products (FDP) and D-dimer levels were measured. Head computerized tomography (CT) findings were categorized as brain edema, linear fracture, depressed fracture, contusion and bleeding. Plt counts, PT, PTT, fibrinogen, FDP, D-dimer levels and CT findings were compared with both GCS and mortality in the first week. Statistical significance was accepted at P