Clonal T-cell lymphoproliferation containing Epstein-Barr (EB) virus DNA in a patient with chronic active EB virus infection.
Clonal T-cell lymphoproliferation containing Epstein-Barr (EB) virus DNA in a patient with chronic active EB virus infection.
复制标题
DOI：
10.1111/j.1349-7006.1989.tb02273.x
复制
发表时间：
1989-03
期刊：
影响因子：
--
通讯作者：
Kawa-Ha K
中科院分区：
文献类型：
--
作者：
Ishihara S;Tawa A;Yumura-Yagi K;Murata M;Hara J;Yabuuchi H;Hirai K;Kawa-Ha K
1例慢性活动性EB巴尔病毒（EBV）感染的10岁男孩在肝衰竭终末期出现T细胞淋巴细胞增生。增殖淋巴细胞表型为CD 3 ±、CD 4 ±和HLA-DR ±。来自这些细胞的基因组DNA证明了两个重排的T细胞受体μ链基因，并且含有EBV基因组。这些发现表明EBV可以感染T淋巴细胞，并可能导致克隆性T淋巴细胞增殖。
A 10‐year‐old boy with chronic active Epstein‐Barr virus (EBV) infection developed T‐cell lymphoproliferation in the terminal stage of hepatic failure. The phenotypes of the proliferating lymphocytes were CD3±, CD4± and HLA‐DR±. The genomic DNAs from these cells demonstrated two rearranged T‐cell receptor μ‐chain genes and contained the EBV genome. These findings indicate that EBV can infect T lymphocytes and might cause clonal T‐cell lymphoproliferation.