Dietary micronutrient intake and risk of progression to acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus type 1 (HIV-1)-infected homosexual men.
Dietary micronutrient intake and risk of progression to acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus type 1 (HIV-1)-infected homosexual men.
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人类免疫缺陷病毒 1 型 (HIV-1) 感染的同性恋男性的膳食微量营养素摄入量和进展为获得性免疫缺陷综合征 (AIDS) 的风险。
DOI：
10.1093/oxfordjournals.aje.a116814
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发表时间：
1993
影响因子：
5
通讯作者：
Saah,AJ
中科院分区：
文献类型：
--
作者：
Tang,AM;Graham,NM;Kirby,AJ;McCall,LD;Willett,WC;Saah,AJ
作者试图确定不同水平的膳食微营养素摄入量是否与人类免疫缺陷病毒1型(HIV-1)感染发展为获得性免疫缺陷综合征(AIDS)有关。自1984年以来，在多中心艾滋病队列研究的巴尔的摩/华盛顿特区站点，总共每半年看到281名HIV-1血清阳性的同性恋/双性恋男子。参与者在基线时完成了一份自我管理的半定量食物频率问卷。在中位数6.8年的随访期内，研究了基线的每日微量营养素摄入水平与随后发展为艾滋病的关系(1987年疾病控制中心定义；n=108)。对于每种营养素，作者使用了COX比例风险模型来调整年龄、症状存在、CD4+淋巴细胞计数、能量摄入、抗逆转录病毒药物的使用以及卡氏肺孢子虫肺炎预防的使用。维生素C、维生素B和烟酸的总摄入量(从食物和补充剂中)越高，艾滋病的进展率就越低：维生素C(相对危险度(RH)=0.55，95%可信区间(CI)0.34~0.91)，维生素B1(RH=0.60，95%CI 0.36~0.98)，烟酸(RH=0.52，95%CI 0.31~0.86)。维生素A总摄入量与病情进展呈U型关系，维生素A摄入量最低和最高的四分位数表现最差，中间两个四分位数的进展速度明显较慢(RH=0.55，95%CI 0.35~0.88)。锌摄入量增加与进展为艾滋病的风险增加单调且显著相关(最高与最低四分位数，RH=2.06，95%CI 1.16=3.64)。在最终的多营养素模型中，维生素A、烟酸和锌仍然与艾滋病的进展显著相关，而维生素C只有轻微的显著意义。
The authors sought to determine if different levels of dietary intake of micronutrients are associated with the progression of human immunodeficiency virus type 1 (HIV-1) infection to acquired immunodeficiency syndrome (AIDS). A total of 281 HIV-1 sero-positive homosexual/bisexual men were seen semiannually since 1984 at the Baltimore/Washington, DC site of the Multicenter AIDS Cohort Study. Participants completed a self-administered semiquantitative food frequency questionnaire at baseline. Levels of daily micronutrient intake at baseline were examined in relation to subsequent progression to AIDS (1987 Centers for Disease Control definition;n= 108) during a median follow-up period of 6.8 years. For each nutrient, the authors used a Cox proportional hazards model to adjust for age, presence of symptoms, CD4+ lymphocyte count, energy intake, use of antiretrovirals, and use ofPneumocystis cariniipneumonia prophylaxis. The highest levels of total intake (from food and supplements) of vitamins C and B, and niacin were associated with a significantly decreased progression rate to AIDS: vitamin C (relative hazard (RH) = 0.55, 95% confidence interval (Cl) 0.34–0.91), vitamin B1(RH = 0.60, 95% Cl 0.36–0.98), and niacin (RH = 0.52, 95% Cl 0.31–0.86). The relation between total vitamin A intake and progression to AIDS appeared to be U-shaped; the lowest and highest quartiles of intake did most poorly, while the middle two quartiles were associated with significantly slower progression to AIDS (RH = 0.55, 95% Cl 0.35–0.88). Increased intake of zinc was monotonically and significantly associated with an increased risk of progression to AIDS (for highest vs. lowest quartiles, RH = 2.06, 95% Cl 1.16=3.64). In a final multinutrient model, vitamin A, niacin, and zinc remained significantly associated with progression to AIDS, while vitamin C was only marginally significant.