Clinical significance of preoperative serum high density lipoprotein cholesterol levels in soft tissue sarcoma.
Clinical significance of preoperative serum high density lipoprotein cholesterol levels in soft tissue sarcoma.
复制标题
软组织肉瘤术前血清高密度脂蛋白胆固醇水平的临床意义
DOI：
10.1097/md.0000000000000844
复制
发表时间：
2015-05
期刊：
影响因子：
1.6
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Que Y;Jiang F;Liu L;Li Y;Chen Y;Qiu H;Zhou Z;Zhang X
补充数字内容可在文本中找到。脂质谱在软组织肉瘤中的预后价值仍不清楚。本研究的目的是验证术前血浆脂质谱（高密度脂蛋白胆固醇 [HDL-C]、低密度脂蛋白胆固醇 [LDL-C]、胆固醇和甘油三酯）水平对接受广泛根治性手术切除的软组织肉瘤 (STS) 患者的无病生存 (DFS) 和总生存 (OS) 的预后价值。回顾性评估2000年至2010年期间接受手术的234例STS患者的术前血脂水平。计算 DFS 和 OS 的 Kaplan-Meier 曲线和多元 Cox 比例模型。在单变量分析中，HDL-C 水平降低与 OS 降低显着相关（风险比 [HR]，3.405；95% 置信区间 (CI)，1.445–8.021，P = 0.005），并且在多变量分析中仍然显着（HR，5.615；95% CI，1.243–25.378， P = 0.025）。 HDL-C<1.475mmol/L 的患者的中位 OS 为 71 个月。相比之下，HDL-C ≥1.475mmol/L 的患者的中位 OS 为 101 个月。在单变量分析中，HDL-C水平降低与DFS降低显着相关（HR，2.085；95% CI，1.271-3.422，P = 0.004），并且在多变量分析中仍然显着（HR，1.808；95% CI，1.118-2.924，P = 0.016）。 HDL-C<1.475mmol/L的患者的中位DFS为47个月，而HDL-C≥1.475mmol/L的患者的中位DFS为78个月。在有关 OS 和 DFS 的单变量分析和多变量分析中，各组之间的 LDL-C、CHO 和 TG 没有显着相关性。我们的研究调查了术前血浆 HDL-C 水平作为接受根治性手术切除的 STS 患者的独立因素的潜在预后效用。
Supplemental Digital Content is available in the text The prognostic value of lipid profile remains unclear in soft tissue sarcoma. The aim of the present study was to validate the prognostic value of preoperative plasma lipid profile (high density lipoprotein-cholesterol [HDL-C], low density lipoprotein-cholesterol [LDL-C], cholesterol, and triglycerides) levels on disease-free survival (DFS) and overall survival (OS) in soft tissue sarcoma (STS) patients undergoing extensive and radical surgical resection. The preoperative plasma lipid profile levels of 234 STS patients, who were operated on between 2000 with 2010, were retrospectively evaluated. Kaplan-Meier curves and multivariate Cox proportional models were calculated for DFS and OS. In univariate analysis, a decreased HDL-C level was significantly associated with decreased OS (hazard ratio [HR], 3.405; 95% confidence interval (CI), 1.445–8.021, P = 0.005) and remained significant in the multivariate analysis (HR, 5.615; 95% CI, 1.243–25.378, P = 0.025). Patients with HDL-C < 1.475 mmol/L showed a median OS of 71 months. In contrast, patients with HDL-C ≥1.475 mmol/L had a median OS of 101 months. In univariate analysis, a decreased HDL-C level was significantly associated with decreased DFS (HR, 2.085; 95% CI, 1.271–3.422, P = 0.004) and remained significant in the multivariate analysis (HR, 1.808; 95% CI, 1.118–2.924, P = 0.016). Patients with HDL-C <1.475 mmol/L presented with a median DFS of 47 months, whereas patients with HDL-C ≥1.475 mmol/L had a median DFS of 78 months. In univariate analysis and multivariate analyses regarding OS and DFS, there was no significant association between the groups in terms of LDL-C, CHO and TG. Our study investigated the potential prognostic utility of preoperative plasma HDL-C levels as an independent factor in STS patients who had undergone radical surgical resection.