Psychological and Sexual Symptoms Associated with the Menopause and the Effects of Hormone Replacement Therapy
Psychological and Sexual Symptoms Associated with the Menopause and the Effects of Hormone Replacement Therapy
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与更年期相关的心理和性症状以及激素替代疗法的效果
DOI：
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发表时间：
1995
影响因子：
10.5
通讯作者：
F. Blake
中科院分区：
文献类型：
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作者：
J. Pearce;K. Hawton;F. Blake
背景关于更年期的心理和性后遗症及其治疗的研究结果存在相当大的不一致性。方法在Medline上检索有关自然或手术绝经或接受激素替代疗法治疗更年期症状的妇女的心理症状的研究文献。结果有证据表明，在自然绝经前和手术绝经后，心理发病率有小幅上升（通常不构成精神障碍）。心理社会和荷尔蒙因素都是相关的。虽然社会心理症状对雌激素激素替代疗法的反应是不同的，在手术绝经期最为明显，但在一些研究中，其效果略高于安慰剂。在出现性症状的地方，有更一致的证据表明激素替代疗法是有效的。根据现有证据，目前使用激素替代疗法治疗在自然绝经时（但不一定是由于自然绝经）发现的心理症状必须受到质疑。雌激素治疗确实能改善手术绝经后的心理症状。
Background There is considerable inconsistency in the results of studies of the psychological and sexual sequelae of the menopause and their treatment. Method A search of the literature on Medline was made of studies of psychological symptoms in women who were either naturally or surgically menopausal or who were receiving hormone replacement therapy for menopausal symptoms. Results There is evidence of a small increase in psychological morbidity (not usually amounting to psychiatric disorder) preceding the natural menopause and following the surgical menopause. Psychosocial as well as hormonal factors are relevant. While the response of psychosocial symptoms to hormone replacement therapy with oestrogens is variable and most marked in the surgical menopause, in some studies the effect is little greater than that for placebo. Where sexual symptoms are present, there is more consistent evidence that hormone replacement therapy is effective. Conclusions In the light of the available evidence, the current use of hormone replacement therapy to treat psychological symptoms detected at the time of (but not necessarily therefore due to) the natural menopause must be questioned. It does appear that oestrogen therapy ameliorates psychological symptoms after surgical menopause.
影响因子：
5.9
作者：
Karen A. Matthews;Rena R. Wing;L. H. Kuller;E. Meilahn;Sheryl F. Kelsey;E. Jane Costello;A. Caggiula
通讯作者：
Karen A. Matthews;Rena R. Wing;L. H. Kuller;E. Meilahn;Sheryl F. Kelsey;E. Jane Costello;A. Caggiula