The antiviral effect of catechins on mumps virus infection
The antiviral effect of catechins on mumps virus infection
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DOI：
10.1016/j.jff.2021.104817
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发表时间：
2021-10-26
影响因子：
5.6
通讯作者：
Takeuchi，Hideyuki
中科院分区：
文献类型：
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作者：
Takahashi，Tadanobu;Kurebayashi，Yuuki;Takeuchi，Hideyuki
已知儿茶素通过抑制病毒受体结合和病毒唾液酸酶活性对甲型和乙型流感病毒具有抗病毒作用。在这里，我们研究了儿茶素对腮腺炎病毒感染的抗病毒作用。在腮腺炎病毒感染Vero细胞的同时加入没食子儿茶素没食子酸酯（EGCG）、没食子儿茶素没食子酸酯、表儿茶素没食子酸酯或儿茶素没食子酸酯可显著抑制感染。在测试的儿茶素中，EGCG显示出最强的抗病毒作用。这些儿茶素对腮腺炎病毒的受体结合和血凝素-神经氨酸酶的唾液酸酶活性没有抑制作用，这与已知的甲型和乙型流感病毒的机制不同。相比之下，这些儿茶素抑制病毒融合活性。我们的结果表明，儿茶素是一种有用的食物来源的抗病毒剂对抗腮腺炎病毒。
Catechins have been known to possess antiviral effects against influenza A and B viruses through the inhibition of both the viral receptor binding and viral sialidase activities. Here, we examined the antiviral effect of catechins on mumps virus infection. The addition of epigallocatechin gallate (EGCG), gallocatechin gallate, epicatechin gallate, or catechin gallate simultaneously with the mumps virus infection of Vero cells greatly inhibited the infection. EGCG showed the strongest antiviral effect among the catechins tested. These catechins did not exhibit an inhibitory effect against the receptor binding and sialidase activities in the hemagglutinin–neuraminidase of the mumps virus, which was different from a known mechanism for influenza A and B viruses. By contrast, these catechins inhibited the viral fusion activity. Our results indicate that catechins are a useful food-derived antiviral agent against the mumps virus.