Cinnamon increases liver glycogen in an animal model of insulin resistance
Cinnamon increases liver glycogen in an animal model of insulin resistance
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DOI：
10.1016/j.metabol.2011.03.016
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发表时间：
2011-11-01
影响因子：
9.8
通讯作者：
Anderson, Richard A.
中科院分区：
文献类型：
--
作者：
Couturier, Karine;Qin, Bolin;Anderson, Richard A.
本研究的目的是确定肉桂对糖原合成的影响，相关基因的表达，和蛋白质水平在肌肉和肝脏使用胰岛素抵抗的动物模型，高脂肪/高果糖（HF/HFr）饮食喂养的大鼠。用（1）HF/HFr饮食诱导胰岛素抵抗，（2）每千克饮食含有20 g肉桂的HF/HFr饮食，（3）对照饮食，和（4）每千克饮食含有20 g肉桂的对照饮食喂养四组22只雄性Wistar大鼠12周。在肝脏中，肉桂添加到HF/HFr饮食导致肝糖原的高度显着增加。食用对照饮食加肉桂的动物没有显著变化。在肝脏中，肉桂还抵消了由于消耗HF/HFr饮食导致的胰岛素受体、胰岛素受体底物1和2、葡萄糖转运蛋白1和2以及糖原合成酶1的基因表达的降低。在肌肉中，HF/HFr饮食和葡萄糖转运蛋白4降低的这些基因的表达也被肉桂逆转。此外，在食用肉桂的动物中，在HF/HFr喂养的大鼠的肌肉中观察到的糖原合成酶3 β信使RNA水平和蛋白质的过表达降低。这些数据表明，在胰岛素抵抗大鼠中，肉桂通过调节胰岛素信号和糖原合成来改善胰岛素敏感性并增强肝糖原。在胰岛素敏感性正常的对照动物中，肉桂引起的变化并不显著。爱思唯尔公司出版
The objective of this study was to determine the effects of cinnamon on glycogen synthesis, related gene expression, and protein levels in the muscle and liver using an animal model of insulin resistance, the high-fat/high-fructose (HF/HFr) diet-fed rat. Four groups of 22 male Wistar rats were fed for 12 weeks with (1) HF/HFr diet to induce insulin resistance, (2) HF/HFr diet containing 20 g cinnamon per kilogram of diet, (3) control diet, and (4) control diet containing 20 g cinnamon per kilogram of diet. In the liver, cinnamon added to the HF/HFr diet led to highly significant increases of liver glycogen. There were no significant changes in animals consuming the control diet plus cinnamon. In the liver, cinnamon also counteracted the decreases of the gene expressions due to the consumption of the HF/HFr diet for the insulin receptor, insulin receptor substrates 1 and 2, glucose transporters 1 and 2, and glycogen synthase 1. In muscle, the decreased expressions of these genes by the HF/HFr diet and glucose transporter 4 were also reversed by cinnamon. In addition, the overexpression of glycogen synthase 3 beta messenger RNA levels and protein observed in the muscle of HF/HFr fed rats was decreased in animals consuming cinnamon. These data demonstrate that, in insulin-resistant rats, cinnamon improves insulin sensitivity and enhances liver glycogen via regulating insulin signaling and glycogen synthesis. Changes due to cinnamon in control animals with normal insulin sensitivity were not significant. Published by Elsevier Inc.