Disturbed frontal gyrification within families affected with schizophrenia
Disturbed frontal gyrification within families affected with schizophrenia
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DOI：
10.1016/j.jpsychires.2006.07.018
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发表时间：
2007-11-01
影响因子：
4.8
通讯作者：
Tepest, Ralf
中科院分区：
文献类型：
--
作者：
Falkai, Peter;Honer, William G.;Tepest, Ralf
目的：最近，在尸检和随后的结构磁共振研究中，精神分裂症患者额叶的脑回指数(GI)显著增加。为了探查额叶高回症是否具有区域特异性，以及这是否可能是寻找精神分裂症遗传基础的合适的内表型，对精神分裂症家系的MRI扫描进行了额部和顶枕部的GI测定。方法：在48例精神分裂症患者、82名一级亲属和41名对照受试者的MRI扫描中，GI分别在胼胝体膝部前的3个层面和压部之后的3个层面进行测定，从而可以选择性地在额叶和顶叶测定这一指标。构成GI的外轮廓和内轮廓在每个部分中都是通过手动描记确定的。结果：精神分裂症患者及正常亲属额部而非顶枕部GI显著高于对照组(右侧7%，F=13.24，df=3,155，p<；0.0005，左侧6%，F=8.92，df=3,155，p<；0.0005)。在受影响的家庭成员和未受影响的家庭成员之间没有总体差异。但在左侧，诊断组和遗传负荷之间存在显著的交互作用(F=4.68，df=2,101，p=0.01)：仅在单病和多病家系中，患病家庭成员的GI显著高于非患病家庭成员。结论：这些结果支持我们在精神分裂症患者额叶的初步发现。与顶叶相比，脑回功能亢进似乎选择性地影响额叶，是一种合适的神经发育指标，甚至可能是一种内表型标志物。(C)2006爱思唯尔有限公司。保留所有权利。
Objective: Recently, in a post-mortem and a subsequent structural MR study, a significantly increased gyrification index (GI) was demonstrated in the frontal lobe in individuals with schizophrenia. To examine whether frontal lobe hypergyria is region-specific and whether this might be a suitable endophenotype in the search for the genetic basis of schizophrenia, the frontal as well as parieto-occipital GI were determined in MRI scans of families affected with schizophrenia.Method: In the MRI scans of 48 subjects suffering from schizophrenia, in 82 of their first-degree relatives and in 41 control subjects, the GI was determined in three sections anterior to the genu of the corpus callosum and three sections posterior to the splenium, thus allowing for a selective determination of this measure in the frontal as well as the parietal lobe. Outer and inner contours constituting the GI was determined in each section by manual tracing. Statistical analysis was performed using MANOVA with factors diagnostic group and intervening factors from preliminary analyses.Results: The frontal, but not parieto-occipital GI was significantly higher in schizophrenic patients as well as unaffected relatives compared with control subjects (right: 7%, F = 13.24, df = 3, 155, p < 0.0005, left: 6%, F = 8.92, df = 3, 155, p < 0.0005). There was no overall difference between affected and unaffected family members. On the left side however, there was a significant interaction between diagnostic group and genetic loading (F = 4.68, df = 2, 101, p = 0.01): significantly higher GI was found in affected compared with unaffected family members only in uniaffected and not multiaffected families.Conclusions: These results support our primary finding of hypergyria in the frontal lobe in schizophrenic patients. Compared to the parietal lobe, hypergyria seems to affect the frontal lobe selectively and serves as a suitable neurodevelopmental, possibly even an endophenotypic marker. (c) 2006 Elsevier Ltd. All rights reserved.