Histologic Assessment and Prognostic Factors of Malignant Pleural Mesothelioma Treated With Extrapleural Pneumonectomy
Histologic Assessment and Prognostic Factors of Malignant Pleural Mesothelioma Treated With Extrapleural Pneumonectomy
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DOI：
10.1309/ajcphv33ljtvdgjj
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发表时间：
2008-11-01
影响因子：
3.5
通讯作者：
Moran, Cesar A.
中科院分区：
文献类型：
--
作者：
Arrossi, Andrea V.;Lin, E.;Moran, Cesar A.
报告胸膜外全肺切除术治疗恶性胸膜间皮瘤56例。对EPP标本的载玻片进行审查，并根据世界卫生组织胸膜肿瘤分类的指导对肿瘤进行分类。评价了EPP审查和诊断程序（DP）报告的组织学类型之间的一致性。组织学和临床参数也与临床结局相关，DP报告和EPP标本审查中的组织学类型之间存在显著差异（P = 0.001）。DP的组织学类型与疾病特异性生存期（DSS）相关;然而，EPP标本的组织学类型与生存期无关。术后治疗与DSS和无复发生存率相关，我们的研究证实，在许多情况下，MPM的最终组织病理学分型受完全手术切除的影响，在治疗分层中应仔细权衡初始活检。
We studied 56 cases of malignant pleural mesothelioma (MPM) treated with extrapleural pneumonectomy (EPP). The slides from the EPP specimens were reviewed, and tumors were classified with the guidance of the World Health Organization classification of pleural tumors. Agreement between the histologic type from the EPP review and the diagnostic procedure (DP) reports was evaluated. Histologic and clinical parameters were also correlated with clinical outcome.There was a significant disagreement (P = 0001) between the histologic type in the DP reports and the EPP specimen review. The histologic type from the DP was associated with disease-specific survival (DSS); however, the histologic type from the EPP specimen was not associated with survival. Postoperative treatment was associated with DSS and with recurrence-free survival.Our study confirms that in many cases, final histopathologic typing of MPM is influenced by complete surgical resection and that initial biopsy should be carefully weighed in the treatment stratification.