Analysis of diversity of mutations in the mecI gene and mecA promoter/operator region of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis
Analysis of diversity of mutations in the mecI gene and mecA promoter/operator region of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis
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DOI：
10.1128/aac.42.3.717
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发表时间：
1998-03-01
影响因子：
4.9
通讯作者：
Urasawa, S
中科院分区：
文献类型：
--
作者：
Kobayashi, N;Taniguchi, K;Urasawa, S
分析了耐甲氧西林金黄色葡萄球菌（MRSA）和表皮葡萄球菌（MRSE）临床分离株的mecI基因或mecA启动子/操纵子区突变的基因组多样性。在大多数MRSA菌株中，在mecI（三个不同的位置）或mecA启动子（两个不同的位置）中检测到单个碱基取代，而在一个菌株中发现mecI中的28个碱基缺失。相比之下，在MRSE菌株的这些基因序列中未检测到突变。
Genomic diversity of mutation in the mecI gene or mecA promoter/operator region was analyzed for clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE). In most MRSA strains, a single base substitution was detected in either the mecI (three different positions) or the mecA promoter (two different positions), while a 28-base deletion in mecI was found in one strain. In contrast, no mutation was detected in these gene sequences of MRSE strains.