Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task
Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task
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DOI：
10.1523/jneurosci.3369-07.2007
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发表时间：
2007-10-17
影响因子：
5.3
通讯作者：
Mitchell, Anna S.
中科院分区：
文献类型：
--
作者：
Baxter, Mark G.;Gaffan, David;Mitchell, Anna S.
眼眶前额叶皮质被认为与灵长类动物的行为灵活性有关，人类神经成像研究已经确定了情景记忆编码过程中眼眶前额叶的激活。本研究的目的是确定是否赤字的策略执行和情景记忆发生后，整个前额叶皮层消融可以归因于眶前额叶皮层的损伤。恒河猴术前训练的两个行为任务，这两个性能严重受损的额叶皮层从颞下皮层的断开。在策略执行任务中，猴子被要求学习两类物体，每一类都与获得食物奖励所必须执行的不同策略相关。不同的策略必须灵活运用，以优化奖励交付率。在场景记忆任务中，猴子在每次会话中学习了20个新的原地物体识别问题。在双侧眶前额叶皮层消融之前和之后，对猴子进行了这两项任务的测试。这些病变损害了新场景学习，但对策略执行没有影响。这一发现支持了眶前额叶皮层在记忆中的作用，但限制了眶前额叶皮层参与行为目标和策略的表征和实施。
The orbital prefrontal cortex is thought to be involved in behavioral flexibility in primates, and human neuroimaging studies have identified orbital prefrontal activation during episodic memory encoding. The goal of the present study was to ascertain whether deficits in strategy implementation and episodic memory that occur after ablation of the entire prefrontal cortex can be ascribed to damage to the orbital prefrontal cortex. Rhesus monkeys were preoperatively trained on two behavioral tasks, the performance of both of which is severely impaired by the disconnection of frontal cortex from inferotemporal cortex. In the strategy implementation task, monkeys were required to learn about two categories of objects, each associated with a different strategy that had to be performed to obtain food reward. The different strategies had to be applied flexibly to optimize the rate of reward delivery. In the scene memory task, monkeys learned 20 new object-in-place discrimination problems in each session. Monkeys were tested on both tasks before and after bilateral ablation of orbital prefrontal cortex. These lesions impaired new scene learning but had no effect on strategy implementation. This finding supports a role for the orbital prefrontal cortex in memory but places limits on the involvement of orbital prefrontal cortex in the representation and implementation of behavioral goals and strategies.