Are there non-invasive markers in human oocytes that can predict pregnancy outcome?
Are there non-invasive markers in human oocytes that can predict pregnancy outcome?
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DOI：
10.1016/s1472-6483(10)60013-2
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发表时间：
2009-05-01
影响因子：
4
通讯作者：
Chapman, Michael
中科院分区：
文献类型：
--
作者：
Kilani, Suha;Cooke, Simon;Chapman, Michael
选择单胚胎移植最佳胚胎的预测标准仍然难以捉摸。本研究旨在确定使用偏光显微镜可检测的人类卵母细胞中的非侵入性标记是否可以预测妊娠结果。来自 19 名患者的 22 个可妊娠的卵母细胞与来自 19 名年龄匹配但移植未导致妊娠的患者的 30 个卵母细胞相比，具有形态学特征。怀孕和非怀孕患者收集的卵母细胞数量相似（平均：11.9 +/- 2.8 与 11.3 +/- 2.9）和相似的受精率（70.1% 与 69.6%）。所有移植的胚胎在第 2 天均处于 4 细胞卵裂阶段
Predictive criteria for selection of the best embryo for single embryo transfer remain elusive. This Study aimed to determine if non-invasive markers in human oocytes, detectable using polarized light microscopy, can predict pregnancy outcome. Twenty-two pregnancy-producing oocytes from 19 patients had their morphological features compared with 30 oocytes from 19 age-matched patients whose transfer did not result in a pregnancy. Both pregnant and non-pregnant patients had similar numbers of oocytes collected (average: 11.9 +/- 2.8 versus 11.3 +/- 2.9) and similar fertilization rates (70.1% versus 69.6%). All embryos transferred were 4-cell cleavage-stage on day 2 with