Metal-free catalytic hydrogenation of polar substrates by frustrated Lewis pairs.
Metal-free catalytic hydrogenation of polar substrates by frustrated Lewis pairs.
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DOI：
10.1021/ic200663v
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发表时间：
2011-05
影响因子：
4.6
通讯作者：
D. Stephan;Sharonna Greenberg;Todd W. Graham;Preston A. Chase;Jeff Hastie;S. Geier;Jeffrey M. Farrell-
中科院分区：
文献类型：
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作者：
D. Stephan;Sharonna Greenberg;Todd W. Graham;Preston A. Chase;Jeff Hastie;S. Geier;Jeffrey M. Farrell-
2006年，我们的团队报道了第一个可逆地激活氢的无金属系统。这一发现被扩展到“阻挫刘易斯对”（FLP）加氢催化剂的发现。这种催化作用正是本文的重点。综述了FLP加氢催化剂的发展和应用，并报道了一些以前未发表的数据。基板的范围得到扩大。最佳条件和官能团的耐受性被认为是和适用于潜在的商业意义的目标。本文还综述了不对称FLP氢化反应的最新进展。展望了FLP加氢催化剂的发展前景。
In 2006, our group reported the first metal-free systems that reversibly activate hydrogen. This finding was extended to the discovery of "frustrated Lewis pair" (FLP) catalysts for hydrogenation. It is this catalysis that is the focal point of this article. The development and applications of such FLP hydrogenation catalysts are reviewed, and some previously unpublished data are reported. The scope of the substrates is expanded. Optimal conditions and functional group tolerance are considered and applied to targets of potential commercial significance. Recent developments in asymmetric FLP hydrogenations are also reviewed. The future of FLP hydrogenation catalysts is considered.