Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex
Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex
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DOI：
10.1093/cercor/bhaa044
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发表时间：
2020-08-01
期刊：
影响因子：
3.7
通讯作者：
Nelken, Israel
中科院分区：
文献类型：
--
作者：
Awwad, Bshara;Jankowski, Maciej M.;Nelken, Israel
检测噪声中的短间隙的能力是评估听觉皮层中的时间分辨率的重要工具。然而，仅仅存在由两个短宽带标记界定的时间间隔的反应是令人惊讶的，因为预期的短期抑制是普遍存在于听觉皮层。在这里，我们在麻醉大鼠体内使用细胞内记录来剖析间隙相关反应背后的突触机制。当缺口由两个短标记物界定时，缺口终止反应由第二标记物的起始引起，其中来自第一标记物的偏移的贡献最小。重要的是，我们表明，差距终止响应是由不同的（可能部分重叠）突触人口比基础的发病反应的第一个标志物。这种额外的突触资源的募集是一种新的机制，有助于间隙检测的重要感知任务。
The ability to detect short gaps in noise is an important tool for assessing the temporal resolution in the auditory cortex. However, the mere existence of responses to temporal gaps bounded by two short broadband markers is surprising, because of the expected short-term suppression that is prevalent in auditory cortex. Here, we used in-vivo intracellular recordings in anesthetized rats to dissect the synaptic mechanisms that underlie gap-related responses. When a gap is bounded by two short markers, a gap termination response was evoked by the onset of the second marker with minimal contribution from the offset of the first marker. Importantly, we show that the gap termination response was driven by a different (potentially partially overlapping) synaptic population than that underlying the onset response to the first marker. This recruitment of additional synaptic resources is a novel mechanism contributing to the important perceptual task of gap detection.