A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumour and its microenvironment: iBD score.
A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumour and its microenvironment: iBD score.
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基于肿瘤及其微环境特征的舌鳞癌预后模型：iBD评分
DOI：
10.1111/his.13790
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发表时间：
2019
期刊：
影响因子：
6.4
通讯作者：
Liu Xiqiang
中科院分区：
文献类型：
--
作者：
Yu Pei;Wang Weiwang;Zhuang Zehang;Xie Nan;Xu Jieyun;Wang Cheng;Hou Jinsong;Han Xiaozhe;Liu Xiqiang
肿瘤微环境（tumor microenvironment， TME）对舌鳞状细胞癌（TSCC）患者的预后价值尚不清楚，但其出芽和浸润深度可以预测患者的生存。本文研究了肿瘤及其微环境的特征，并提出了一种新的预后模型。方法与结果共纳入246例TSCC患者。采用H&E染色切片，评估肿瘤病理参数和TME。炎症反应(i)、肿瘤出芽(B)和侵入深度(D)合并作为iBD评分。确定了这些变量与患者生存率之间的关系。肿瘤出芽和炎症状态都是预测TSCC患者总生存期（OS）和无病生存期（DFS）的独立变量。浸润深度与肿瘤分化、T分型、淋巴结转移、临床分期及复发相关（P< 0.05）。新型iBD模型与T分型、淋巴结转移、临床分期、复发密切相关，且0分、1分、2分差异明显。iBD评分越高，OS和DFS越低（P< 0.01）。结论iBD评分模型与TSCC的淋巴结转移和复发密切相关，有望成为TSCC患者生存的预测指标。
AimsTumour budding and invasive depth can predict survival of patients with tongue squamous cell carcinoma (TSCC), while the prognostic value of tumour microenvironment (TME) remains unknown. Here, both characteristics of the tumour and its microenvironment were examined and a novel prognostic model has been proposed.Methods and resultsA total of 246 patients with TSCC were included. Using H&E‐stained sections, pathological parameters of tumour and the TME were assessed. Inflammatory response (i), tumour budding (B) and invasive depth (D) were combined as iBD score. The association between these variables and the patient survival was determined. Both tumour budding and inflammatory status were independent variables for predicting overall survival (OS) and disease‐free survival (DFS) of TSCC patients. Invasive depth was correlated with differentiation, T classification, lymph node metastasis, clinical stage and recurrence (P< 0.05). The novel iBD model was strongly correlated with T classification, lymph node metastasis, clinical stage and recurrence, and showed clear distinction of scores 0, 1 and 2. High iBD score had a strong association with reduced OS and DFS (P< 0.01).ConclusionsThe iBD scoring model is strongly associated with lymph node metastasis and recurrence in TSCC and could be a promising survival predictor for TSCC patients.