Effect of exercise intensity on postprandial lipemia, markers of oxidative stress, and endothelial function after a high-fat meal
Effect of exercise intensity on postprandial lipemia, markers of oxidative stress, and endothelial function after a high-fat meal
复制标题
DOI：
10.1139/apnm-2016-0262
复制
发表时间：
2016-12-01
影响因子：
3.4
通讯作者：
Reischak-Oliveira, Alvaro
中科院分区：
文献类型：
--
作者：
Kruger, Renata Lopes;Teixeira, Bruno Costa;Reischak-Oliveira, Alvaro
本研究的目的是比较2种不同运动强度对高脂餐（HFM）后餐后血脂、氧化应激标志物和内皮功能的影响。11名年轻男性在3种条件下完成了为期2天的试验：休息，中等强度运动（MI运动）和高强度运动（HI运动）。受试者在第1天晚上进行运动或不运动（休息）。在第2天早上，提供HFM。在空腹（0 h）和餐后1 - 5 h每小时采集一次血样，测定三酰甘油（TAG）、硫代巴比妥酸反应物质（TBARS）和亚硝酸盐/硝酸盐（NOx）浓度。还分析了血流介导的扩张（FMD）。餐后运动状态下TAG浓度较安静状态下降低（P <0.004）。与休息相比，HI-运动后TAG增量曲线下面积（iAUC）较小（P = 0.012）。MI-运动组TBARS浓度较安静组降低（P <0.041）。0 h时运动状态下FMD高于静息状态（P <0.02），MI-运动状态下NO浓度高于静息状态（P <0.01）。这些结果表明，急性运动可以减少HFM后的脂血症。然而，高强度运动在降低iAUC TAG方面更有效，这可能表明对餐后TAG增强的保护作用更强。相反，与休息相比，MI运动可以有益于减弱由HFM诱导的氧化损伤的易感性，并增加空腹状态下的内皮功能。
The aim of this study was to compare the effects of 2 different exercise intensities on postprandial lipemia, oxidative stress markers, and endothelial function after a high-fat meal (HFM). Eleven young men completed 2-day trials in 3 conditions: rest, moderate-intensity exercise (MI-Exercise) and heavy-intensity exercise (HI-Exercise). Subjects performed an exercise bout or no exercise (Rest) on the evening of day 1. On the morning of day 2, an HFM was provided. Blood was sampled at fasting (0 h) and every hour from 1 to 5 h during the postprandial period for triacylglycerol (TAG), thiobarbituric acid reactive substance (TBARS), and nitrite/nitrate (NOx) concentrations. Flow-mediated dilatation (FMD) was also analyzed. TAG concentrations were reduced in exercise conditions compared with Rest during the postprandial period (P < 0.004). TAG incremental area under the curve (iAUC) was smaller after HI-Exercise compared with Rest (P = 0.012). TBARS concentrations were reduced in MI-Exercise compared with Rest (P < 0.041). FMD was higher in exercise conditions than Rest at 0 h (P < 0.02) and NOx concentrations were enhanced in MI-Exercise compared with Rest at 0 h (P < 0.01). These results suggest that acute exercise can reduce lipemia after an HFM. However, HI-Exercise showed to be more effective in reducing iAUC TAG, which might suggest higher protection against postprandial TAG enhancement. Conversely, MI-Exercise can be beneficial to attenuate the susceptibility of oxidative damage induced by an HFM and to increase endothelial function in the fasted state compared with Rest.