Inhibition of secretion of interleukin-1α and tumor necrosis factor alpha by the ketolide antibiotic telithromycin
Inhibition of secretion of interleukin-1α and tumor necrosis factor alpha by the ketolide antibiotic telithromycin
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DOI：
10.1128/aac.46.10.3327-3330.2002
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发表时间：
2002-10-01
影响因子：
4.9
通讯作者：
Remington, JS
中科院分区：
文献类型：
--
作者：
Araujo, FG;Slifer, TL;Remington, JS
我们检测了抗生素特利霉素对8个人供体脂多糖刺激单核细胞分泌白细胞介素-1 α (il -1 α)、il -1 β、IL-6、IL-10和肿瘤坏死因子α (tnf - α)的影响。单独LPS可显著增加各细胞因子的分泌，而特利霉素可显著抑制il -1 α和tnf - α的分泌，但不能抑制il -1 β、IL-6和IL-10的分泌。Telithromycin通过改变单核细胞分泌il -1 α和tnf - α而具有免疫调节作用。
The antibiotic telithromycin was examined for its effect on secretion of interleukin-1alpha (IL-1alpha), IL-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide (LPS)-stimulated monocytes of eight human donors. Secretion of each cytokine was significantly increased by LPS alone, whereas treatment with telithromycin significantly inhibited secretion of IL-1alpha and TNF-alpha but not secretion of IL-1beta, IL-6, and IL-10. Telithromycin had immunomodulatory effects as a result of alteration of secretion of IL-1alpha and TNF-alpha by monocytes.