[Epithelial-mesenchymal transition in cancer progression].
[Epithelial-mesenchymal transition in cancer progression].
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发表时间：
2009
影响因子：
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通讯作者：
M. Gos;J. Miłoszewska;M. Przybyszewska
中科院分区：
文献类型：
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作者：
M. Gos;J. Miłoszewska;M. Przybyszewska
根据最近发表的数据，上皮-间质转化-一个对胚胎发育很重要的过程，可能涉及许多病理过程，如伤口愈合、组织纤维化或癌症进展。细胞中的EMT过程由生长因子（EGF、PDGF、HGF）或其他信号传导蛋白如TGF-β、音刺猬蛋白（Shh）、Wnt/β-连环蛋白和细胞外基质（ECM）组分驱动，其可以刺激细胞生长和迁移。在癌症进展过程中，EMT过程对于良性肿瘤向侵袭性和高度侵袭性癌症的转化是必要的。这是由于癌细胞及其微环境的复杂变化导致细胞内连接的溶解及其从基底外侧膜的脱离，以及癌细胞与ECM之间相互作用的变化。粘附的丧失伴随着癌细胞的分子和形态学变化，这些变化对于从上皮细胞向间质细胞的表型变化以及获得更高的迁移和侵袭潜力是必不可少的。在远处位点的定殖期间，发生逆过程间充质-上皮转化（MET），并且转移性癌细胞再次获得上皮表型。癌症进展中的EMT不仅特异于癌细胞。已经提出，肿瘤微环境中的细胞，例如癌症相关成纤维细胞（CAF），也部分地由EMT过程中的正常上皮细胞产生。对EMT和MET过程在癌症进展中的作用及其与癌症干细胞、癌症相关成纤维细胞和其他基质细胞的关系的理解可能会导致发现新的靶向癌症疗法。
According to recently published data, the epithelial-mesenchymal transition--a process important for embryonic development, may be involved in many pathological processes such as wound healing, tissue fibrosis or cancer progression. The EMT process in cell is driven by growth factors (EGF, PDGF, HGF) or other signaling proteins such as TGF-beta, sonic hedgehog (Shh), Wnt/beta-catenin and extracellular matrix (ECM) components that may stimulate cellular growth and migration. During cancer progression, the EMT process is necessary to the conversion of benign tumor to aggressive and highly invasive cancer. This is due to complex changes in cancer cells and their microenvironment that lead to dissolution of intracellular junctions and their detachment from basolateral membrane, and changes in the interactions between cancer cells and ECM. The loss of adhesion is accompanied by molecular and morphologic changes in cancer cells that are essential for the phenotypic change from epithelial to mesenchymal one, and the acquirement of higher migration and invasion potential. During the colonization of distant sites, a reverse process mesenchymal-epithelial transition (MET) takes place and metastatic cancer cells again acquire the epithelial phenotype. The EMT in cancer progression is not only specific for cancer cells. It has been suggested that also cells within tumor microenvironment e.g. cancer associated fibroblasts (CAF) are generated in part from normal epithelial cells in EMT process. The understanding of the role of EMT and MET processes in cancer progression and their relationship with cancer stem cells, cancer associated fibroblasts and other stroma cells might lead to the discovery of new, targeted cancer therapies.