MAGNETIC-RESONANCE-IMAGING AND SPECTROSCOPY IN FETAL ETHANOL-EXPOSED MACACA-NEMESTRINA
MAGNETIC-RESONANCE-IMAGING AND SPECTROSCOPY IN FETAL ETHANOL-EXPOSED MACACA-NEMESTRINA
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DOI：
10.1016/0892-0362(95)00012-g
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发表时间：
1995-09-01
影响因子：
2.9
通讯作者：
CLARREN, SK
中科院分区：
文献类型：
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作者：
ASTLEY, SJ;WEINBERGER, E;CLARREN, SK
磁共振成像（MRI）和质子磁共振波谱（H-1-MRS）提供了一种无创的方法来观察胎儿的结构和生化变化，这可能是检测产前乙醇畸胎性脑损伤的有价值的诊断标志物。研究人员对20名非人类灵长类动物（猕猴）进行了颅磁共振成像和光谱分析，这些灵长类动物已知产前乙醇暴露，并有充分的认知和行为表现水平记录。H-1-MRS检测脑胆碱：肌酸比值随子宫内乙醇暴露时间延长而显著升高。这些信号改变发生在没有总体脑结构异常（通过MRI检测）的情况下，并且与酒精相关的认知和行为功能障碍显著相关。这些观察结果与胆碱：肌酸比值升高与各种神经损伤和疾病状态相关的报道一致。脑胆碱：肌酸比值与子宫内乙醇暴露之间的关联表明H-1-MRS在阐明乙醇致畸机制中的作用。
Magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (H-1-MRS) offer noninvasive ways to observe structural and biochemical changes which might serve as valuable diagnostic markers for detecting brain damage from prenatal ethanol teratogenesis. Cranial MR imaging and spectroscopy were performed on 20 nonhuman primates (Macaca nemestrina) with known prenatal ethanol exposures and well-documented cognitive and behavioral levels of performance. The choline:creatine ratio detected by H-1-MRS in the brain increased significantly with increasing duration of in utero ethanol exposure. These signal alterations occurred in the absence of gross structural brain anomalies (detectable by MRI) and were significantly correlated with alcohol-related cognitive and behavioral dysfunction. These observations are consistent with reports of elevated choline:creatine ratios associated with various neurologic insults and disease states. The association observed between brain choline:creatine ratios and in utero ethanol exposure suggest a role for H-1-MRS in elucidating mechanisms of ethanol teratogenicity.