Effects of moderate and intensive training on the hypothalamo-pituitary-adrenal axis in rats
Effects of moderate and intensive training on the hypothalamo-pituitary-adrenal axis in rats
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DOI：
10.1046/j.1365-201x.2002.00971.x
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发表时间：
2002-06-01
期刊：
影响因子：
--
通讯作者：
Guezennec, CY
中科院分区：
文献类型：
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作者：
Chennaoui, M;Merino, DG;Guezennec, CY
本文研究了中等强度（M）和大强度（I）两种不同训练方案对大鼠下丘脑-垂体-肾上腺（HPA）轴的影响。血浆促肾上腺皮质激素（ACTH）和皮质酮浓度的变化，其次是响应（i）60分钟的急性运行期进行的第2，第4和第6的7个训练周（ii）急性束缚应激40分钟后，最后的训练计划。在两个训练计划的第2、4和6周后，与基线值（即跑步前）和久坐组（S）相比，60分钟跑步导致ACTH和皮质酮分泌增加。但第4、6周与第2周相比，强化组ACTH和皮质酮仍明显升高，而中度组ACTH和皮质酮明显降低。我们可以认为，适度的训练导致了适应性激素反应，而一个不适应的过程发生在密集的计划。在最后一次训练后的第二天，基础ACTH、皮质酮和皮质类固醇结合球蛋白（CBG）的能力没有受到训练的影响。下丘脑促肾上腺皮质激素释放因子组织含量（CRF）在两个训练组显着增加。与安静组相比，两个训练组大鼠的体重均显著降低，肾上腺总质量增加，但仅在强化组。在训练和久坐的动物中，施加的束缚应激导致血浆ACTH和皮质酮的显着增加。这一结果表明，由中等强度和高强度训练诱导的适应性HPA轴反应并不能阻止新应激（如束缚应激）的影响。
The influence of the two distinct training programmes, moderate (M) and intensive (I), on hypothalamo-pituitary-adrenal (HPA) axis was investigated, in rats. Changes in plasma concentrations of adrenocorticotropin hormone (ACTH) and corticosterone were followed in response to (i) a 60-min acute running session performed on 2nd, 4th and 6th of the seven training weeks (ii) an acute restraint stress of 40 min applied after the final training programme. After 2nd, 4th and 6th week of the two training programmes, a 60-min running resulted in an enhanced secretion of ACTH and corticosterone, compared with both the baseline values (i.e. before running) and to the sedentary (S) group. However, on 4th and 6th weeks compared with 2nd week, ACTH and corticosterone remained elevated in intensive group when they are significantly reduced in moderate group. We could suggest that a moderate training resulted in an adapted hormonal response whereas a deadapted process occurred for the intensive programme. The day after the last training session, basal ACTH, corticosterone and corticosteroid-binding globulin (CBG) capacity were not affected by training. Hypothalamic corticotropin-releasing factor tissue-content (CRF) was increased significantly in the two trained groups. When compared with the sedentary group, the body weight of the rats in the two trained groups was significantly decreased with a total adrenal mass increasing but only in intensive group. The surimposed restraint stress resulted in significant increases in plasma ACTH and corticosterone both in trained and in sedentary animals. This result suggests that the adapted HPA axis response induced by both a moderate and intensive training do not prevent against the effects of a novel stress such as restraint stress.