Seasonal influenza vaccine elicits heterosubtypic immunity against H5N1 that can be further boosted by H5N1 vaccination
Seasonal influenza vaccine elicits heterosubtypic immunity against H5N1 that can be further boosted by H5N1 vaccination
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DOI：
10.1016/j.vaccine.2009.12.008
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发表时间：
2010-02-17
期刊：
影响因子：
5.5
通讯作者：
Howard, M. Keith
中科院分区：
文献类型：
--
作者：
van Maurik, Andre;Sabarth, Nicolas;Howard, M. Keith
最近的研究结果表明，季节性流感疫苗接种或健康人的感染可能有助于针对新的甲型流感亚型（例如 H5N1）的异亚型免疫。在这里，我们研究了小鼠模型中的季节性流感疫苗接种是否可以诱导针对 H5N1 亚型的免疫力。可以证明，很大程度上由于 H1N1 成分毒株 A/NewCaledonia/20/99，用三价季节性流感疫苗对小鼠进行胃肠外免疫可引发异亚型 H5 反应性抗体，能够提供针对 H5N1 流感病毒感染的部分保护。此外，三价季节性流感疫苗被发现与异源初免-加强免疫方案中的全病毒H5N1疫苗相容，与同等低剂量H5N1疫苗的单次免疫相比，取得了更佳的功效。 (C) 2009 Elsevier Ltd. 保留所有权利。
Recent findings indicate that seasonal influenza vaccination or infection of healthy humans may contribute to heterosubtypic immunity against new influenza A subtypes, such as H5N1. Here, we investigated whether seasonal influenza vaccination in a mouse model could induce any immunity against the H5N1 subtype. It could be demonstrated that, largely due to the H1N1 component strain A/NewCaledonia/20/99, parenteral immunization of mice with a trivalent seasonal influenza vaccine elicited heterosubtype H5-reactive antibodies able to confer partial protection against H5N1 influenza virus infection. Furthermore, the trivalent seasonal influenza vaccine was found to be compatible with a whole virus H5N1 vaccine in a heterologous prime-boost immunization regimen, achieving superior efficacy compared to a single immunization with an equivalent low-dose of the H5N1 vaccine. (C) 2009 Elsevier Ltd. All rights reserved.