Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficient mice
Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficient mice
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DOI：
10.1016/j.mce.2007.10.012
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发表时间：
2008-02-13
影响因子：
4.1
通讯作者：
Nishimori, Katsuhiko
中科院分区：
文献类型：
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作者：
Kawamata, Masaki;Yoshida, Masahide;Nishimori, Katsuhiko
子宫肌层中催产素（OT）受体（OTR）的急剧增加以及循环孕酮的戒断被认为是诱导和完成分娩的最重要因素，因为在前列腺素F-2 α受体（FP）敲除（FP KO）小鼠中分娩失败。FP KO小鼠近期子宫中OTR mRNA/蛋白的表达水平并未显着增加。然而，OT诱导的子宫肌层收缩和FP KO中的体外浓度-反应曲线与野生型（WT）小鼠几乎相似。OT-输注（0.3U/天）使FP KO小鼠能够经历成功的递送，并且此外，直到发作的持续时间被更高剂量的OT（3U/天）加速。FP KO雌性动物的血浆孕酮水平维持在高水平，但在分娩期间通过OT输注（0 U/天）降低。这些结果表明，OT具有诱导子宫肌层强烈收缩的潜力，而卵巢中OTR的表达水平较低，并导致黄体溶解，从而使Fl？KO雌性进行成功分娩。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
The dramatic increase of oxytocin (OT) receptor (OTR) in the myometrium as well as circulating progesterone withdrawal has been thought to be the most important factor in the induction and accomplishment of parturition since delivery fails in prostaglandin F-2 alpha receptor (FP) knockout (FP KO) mice. The expression levels of OTR mRNA/protein were not dramatically increased in the near-term uteri of FP KO mice. However, OT-induced myometrial contractions and the concentration-response curves in FP KO in vitro were almost similar to those in wild-type (WT) mice. OT-infusion (0.3 U/day) enabled FP KO mice to experience successful delivery, and furthermore the duration until the onset was hastened by a higher dose of OT (3 U/day). The plasma progesterone levels of FP KO females were maintained at high levels, but decreased during labor by OT-infusion Q U/day). These results suggest that OT has potentials to induce strong myometrial contractions in uterus with low expression levels of OTR and luteolysis in ovary, which enabled Fl? KO females to undergo successful delivery. (C) 2007 Elsevier Ireland Ltd. All rights reserved.