DNA damage and repair in human skin: pathways and questions.
DNA damage and repair in human skin: pathways and questions.
复制标题
人类皮肤的 DNA 损伤和修复：途径和问题。
DOI：
10.1007/978-1-4613-0637-5_12
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Sutherland,JC
中科院分区：
文献类型：
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作者：
Sutherland,BM;Hacham,H;Gange,RW;Maytum,D;Sutherland,JC
皮肤是人体内部器官和外部环境之间的主要屏障，每天都受到物理和化学致癌物、促进剂和对这些物质的生物反应的修饰剂的攻击。DNA是大多数致癌物的主要目标，皮肤中的DNA尤其危险。它不仅受到摄入的化合物及其代谢产物的损害，而且还受到外部应用或遇到的化学品以及物理致癌物如阳光和紫外线辐射的化妆品或医疗来源的损害。三个主要因素决定了皮肤DNA损伤与该损伤的生物学后果之间的平衡：（1）损伤的频率和类型，（2）个体修复损伤的能力，以及（3）皮肤用于处理在不同环境条件下造成的不同光谱损伤的策略。因此，细胞对DNA损伤的反应，包括DNA损伤的修复，是决定最终损伤水平及其后果的关键因素。
Skin, the principal barrier between human internal organs and the external environment, is assaulted daily with physical and chemical carcinogens, promoters, and modifiers of biological responses to such agents. DNA is the principal target for most carcinogens, and DNA in skin is particularly at risk. It is subject to damage not only from ingested compounds and their metabolic products, but also from externally applied or encountered chemicals, as well as from physical carcinogens such as sunlight and cosmetic or medical sources of ultraviolet radiation. Three major factors determine the balance between damage to DNA of skin and the biological consequences of that damage: (1) the frequencies and types of lesions, (2) the ability of the individual to repair a lesion, and (3) the strategy that skin employs to deal with the different spectra of lesions inflicted under varying environmental conditions. Thus, cellular responses to DNA damage, including repair of DNA lesions, are critical factors in determining the final level of damage and its consequences.