Altered processing of emotional stimuli in migraine: An event-related potential study
Altered processing of emotional stimuli in migraine: An event-related potential study
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DOI：
10.1177/0333102412459573
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发表时间：
2012-11-01
期刊：
影响因子：
4.9
通讯作者：
Muehlberger, Andreas
中科院分区：
文献类型：
--
作者：
Andreatta, Marta;Puschmann, Anne Kathrin;Muehlberger, Andreas
背景：偏头痛患者报告心理社会压力是偏头痛发作的主要诱因之一。偏头痛发作的潜在机制尚未完全了解。神经影像学研究显示，偏头痛患者的皮质兴奋性发生了变化。在这里，我们调查了大脑皮层激活相关的个人偏头痛emotional.Method：24名参与者患有偏头痛发作和25名健康志愿者的情绪面部表情（愤怒，快乐和中性）的图片被动观察的情绪刺激的处理。通过脑电图（EEG）连续记录皮层电活动，并收集效价（不愉快与愉快）和唤醒（平静与兴奋）的评级。结果：偏头痛和对照组没有不同的视觉刺激的效价和唤醒的评级。然而，偏头痛的参与者，与健康对照组相比，表现出更大的N170振幅对愤怒的面部表情相比，中性的。因此，这些人可能会优先处理高唤醒和威胁事件，这种促进处理可能与他们已经很高的皮层兴奋性有关。
Background: Migraine patients report psychosocial stress to be among the major triggers for their migraine attacks. The mechanisms underlying the onset of migraine attacks are not yet fully understood. Neuroimaging studies have shown changes in the cortical excitability of migraine patients. Here, we investigated cortical activation related to processing of emotional stimuli in individuals with migraine.Method: Twenty-four participants suffering from migraine attacks and 25 healthy volunteers had to passively observe pictures of emotional facial expressions (angry, happy and neutral). Electro-cortical activity was continuously recorded by means of an electroencephalogram (EEG), and ratings of valence (unpleasant vs. pleasant) and arousal (calm vs. exciting) were collected.Results: The migraine and control group did not differ in their ratings of valence and arousal of the visual stimuli. However, participants with migraine, in contrast to healthy controls, showed larger N170 amplitudes toward angry facial expressions compared to neutral ones.Discussion: Individuals with migraine may have an altered cortical activity linked to the processing of emotional information. Thus, these individuals may process high arousing and threatening events preferentially, and this facilitated processing may be related to their already high cortical excitability.