Macula Densa Sensing and Signaling Mechanisms of Renin Release
Macula Densa Sensing and Signaling Mechanisms of Renin Release
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DOI：
10.1681/asn.2009070759
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发表时间：
2010-07-01
影响因子：
13.6
通讯作者：
Harris, Raymond C.
中科院分区：
文献类型：
--
作者：
Peti-Peterdi, Janos;Harris, Raymond C.
根据经典范例，远端肾单位中的致密斑细胞是盐传感器，其在肾小球装置中产生旁分泌化学信号以控制重要的肾功能，包括肾血流、肾小球滤过和肾素释放。肾素是激活肾素-血管紧张素系统的限速步骤，该系统是体液稳态的关键调节剂。在这里，我们讨论了最近的进展，了解致密斑传感，并建议这些细胞，除了盐，也感觉到各种化学和代谢信号的肾小管环境中，直接触发肾素释放。
Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release. Renin is the rate-limiting step in the activation of the renin-angiotensin system, a key modulator of body fluid homeostasis. Here, we discuss recent advances in understanding macula densa sensing and suggest these cells, in addition to salt, also sense various chemical and metabolic signals in the tubular environment that directly trigger renin release.