LIPID MODIFICATIONS OF G-PROTEINS
LIPID MODIFICATIONS OF G-PROTEINS
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DOI：
10.1016/0955-0674(94)90139-2
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发表时间：
1994-04-01
影响因子：
7.5
通讯作者：
CASEY, PJ
中科院分区：
文献类型：
--
作者：
CASEY, PJ
脂质的共价附着是真核细胞指导并在某些情况下控制G蛋白膜定位的一种近乎普遍的机制。在过去的一年中进行的研究，大大提高了我们的分子机制和这些修改的功能后果的理解。特别值得注意的是异源三聚体G蛋白的α-亚基的棕榈酰化和单体G蛋白的Ras超家族成员的异戊二烯化的过程，其中最近的发现指出脂质修饰在通过这些蛋白质的信号传导中的意想不到的作用。
Covalent attachment of lipids is a near-universal mechanism through which eukaryotic cells direct and, in some cases, control membrane localization of G proteins. Studies conducted over the past year have substantially advanced our understanding of both the molecular mechanisms and the functional consequences of these modifications. Of particular note are the processes of palmitoylation of the alpha-subunits of heterotrimeric G proteins, and prenylation of members of the Ras superfamily of monomeric G proteins, where recent findings point to unexpected roles for lipid modifications in signaling through these proteins.