A Brain to Spine Interface for Transferring Artificial Sensory Information.
A Brain to Spine Interface for Transferring Artificial Sensory Information.
复制标题
用于传输人工感觉信息的大脑到脊柱接口。
DOI：
10.1038/s41598-020-57617-3
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发表时间：
2020
影响因子：
4.6
通讯作者：
Nicolelis,MiguelAL
中科院分区：
文献类型：
--
作者：
Yadav,AmolP;Li,Daniel;Nicolelis,MiguelAL
缺乏感觉反馈是大脑快速吸收假肢装置的主要障碍。虽然皮层和皮层下结构的电刺激提供了将感觉信息传递到更高脑结构的独特手段，但这些方法需要高度侵入性的手术，并且依赖于脑结构的准确靶向。在这里，我们提出了一种半侵入性的方法，背柱刺激（DCS）作为一种工具，将感官信息传递到大脑。使用这种新的方法，我们表明，大鼠可以学习歧视DCS产生的人工感觉和DCS诱导的学习结果在皮质纹状体可塑性。我们还展示了一个证明的概念脑-脊柱接口（BTSI），触觉和人工感觉信息从大脑的“编码器”大鼠解码，转化为DCS脉冲，并提供给脊髓的第二个“解码器”大鼠，而后者执行模拟到数字转换在感觉的歧视任务。这些结果表明，DCS可以被用作一个有效的感觉通道，将假体信息传输到大脑或大脑之间，并可以开发为一个新的平台，用于提供触觉和本体感觉反馈的脑机接口的临床应用。
Lack of sensory feedback is a major obstacle in the rapid absorption of prosthetic devices by the brain. While electrical stimulation of cortical and subcortical structures provides unique means to deliver sensory information to higher brain structures, these approaches require highly invasive surgery and are dependent on accurate targeting of brain structures. Here, we propose a semi-invasive method, Dorsal Column Stimulation (DCS) as a tool for transferring sensory information to the brain. Using this new approach, we show that rats can learn to discriminate artificial sensations generated by DCS and that DCS-induced learning results in corticostriatal plasticity. We also demonstrate a proof of concept brain-to-spine interface (BTSI), whereby tactile and artificial sensory information are decoded from the brain of an “encoder” rat, transformed into DCS pulses, and delivered to the spinal cord of a second “decoder” rat while the latter performs an analog-to-digital conversion during a sensory discrimination task. These results suggest that DCS can be used as an effective sensory channel to transmit prosthetic information to the brain or between brains, and could be developed as a novel platform for delivering tactile and proprioceptive feedback in clinical applications of brain-machine interfaces.