Antidiabetic vanadium(IV) and zinc(II) complexes
Antidiabetic vanadium(IV) and zinc(II) complexes
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DOI：
10.1016/s0010-8545(01)00447-7
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发表时间：
2002-03-01
影响因子：
20.6
通讯作者：
Yasui, H
中科院分区：
文献类型：
--
作者：
Sakurai, H;Kojima, Y;Yasui, H
糖尿病（DM）会产生许多继发并发症，如动脉粥样硬化、微血管病变、肾功能障碍和衰竭、心脏异常、糖尿病视网膜病变和眼部疾病，根据世界卫生组织的定义，糖尿病被分为胰岛素依赖型 I 型或非胰岛素依赖型 2 型。尽管已经开发出多种类型的用于1型糖尿病的胰岛素制剂和用于2型糖尿病的合成药物并投入临床使用，但它们分别存在一些问题，例如每日注射胰岛素造成的身体和精神痛苦以及涉及副作用的缺陷。在21世纪，应该推出一类新的药物。因此，含有钒和锌离子的金属药物化合物有望通过有效利用金属的独特特性来治疗这两种类型的糖尿病。本文综述了不同配位方式的模拟胰岛素钒锌配合物的研究现状，重点介绍了配合物的制备、配位结构、体内外评价以及可能的作用机制。 (C) 2002 Elsevier Science B.V. 保留所有权利。
Diabetes mellitus (DM), which develops many secondary complications such as atherosclerosis, microangiopathy, renal dysfunction and failure, cardiac abnormality, diabetes retinopathy and ocular disorders, is classified as either insulin-dependent type I or non-insulin-dependent type 2, according to the definition of WHO. Although several types of insulin preparations for type 1 DM and those of synthetic drugs for type 2 DM have been developed and clinically used, they have several problems such as physical and mental pain due to daily insulin injections and defects involving side effects, respectively. In the 21st century, a new class of pharmaceuticals should be introduced. For this reason, metallopharmaceutical compounds containing vanadium and zinc ions are expected to treat both types of DM, by making effective use of unique characteristics of the metals. In this article, the current state of development of insulin-mimetic vanadium and zinc complexes with different coordination modes are reviewed, focusing on the preparations and coordination structures of the complexes and in vitro and in vivo evaluations as well as the possible mechanism. (C) 2002 Elsevier Science B.V. All rights reserved.