SIN3A mutations are rare in men with azoospermia
SIN3A mutations are rare in men with azoospermia
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SIN3A 突变在无精症男性中很少见
DOI：
10.1111/and.12379
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发表时间：
2015
期刊：
影响因子：
2.4
通讯作者：
Ueda Y,Namiki M,Sengoku K
中科院分区：
文献类型：
--
作者：
Miyamoto T;Koh E;Tsujimura A;Miyagawa Y;Minase G;Ueda Y,Namiki M,Sengoku K
murineSin3A基因的功能丧失导致小鼠中具有仅支持细胞综合征（SCOS）表型的雄性不育。在这里，我们调查了该基因与人类男性不育与无精子症引起的SCOS。对80名日本患者进行了编码区SIN3A的突变分析。然而，未检测到任何变体。本研究提示SIN 3A基因序列变异与SCOS引起的人类无精子症无关联。
A loss of function of the murineSin3Agene resulted in male infertility with Sertoli cell‐only syndrome (SCOS) phenotype in mice. Here, we investigated the relevance of this gene to human male infertility with azoospermia caused by SCOS. Mutation analysis ofSIN3Ain the coding region was performed on 80 Japanese patients. However, no variants could be detected. This study suggests a lack of association ofSIN3Agene sequence variants with azoospermia caused by SCOS in humans.