Translocation, transfer, and in vivo safety evaluation of engineered nanomaterials in the non-mammalian alternative toxicity assay model of nematode Caenorhabditis elegans
Translocation, transfer, and in vivo safety evaluation of engineered nanomaterials in the non-mammalian alternative toxicity assay model of nematode Caenorhabditis elegans
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DOI：
10.1039/c2ra22798c
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发表时间：
2013-04
期刊：
影响因子：
3.9
通讯作者：
Yunli Zhao;Qiuli Wu;Yiping Li;Dayong Wang
中科院分区：
文献类型：
--
作者：
Yunli Zhao;Qiuli Wu;Yiping Li;Dayong Wang
本文对工程纳米材料在秀丽隐杆线虫非哺乳动物替代试验模型中的移位、转移和安全性评价进行了总结和讨论。由于工程纳米材料在工业、农业、医学和公共卫生等领域的广泛应用，工程纳米材料不可避免地会暴露于人类和环境中，因此工程纳米材料的迁移、转移和毒理学研究受到广泛关注。模拟线虫C. elegans是一种公认的非哺乳动物替代毒性检测系统，在环境安全评价、毒理学研究、毒物迁移和转移检测等方面具有重要的应用价值。本文对C.线虫在环境安全性评价、毒理学以及ENMs的移位和转移研究中的作用。我们介绍了急性和慢性毒性测定系统，并讨论了环境安全性评估的特定ENMs在预测的环境相关浓度，和影响的化学性质的ENMs，暴露途径，发育，遗传或生理状态，和环境因素对线虫的纳米毒性形成。主要从氧化应激在正常和应激条件下的作用及信号转导途径、生殖毒理学、神经毒理学以及ENMs在C.优雅的进一步讨论了通过表面设计化学修饰来消除或降低特定ENMs毒性的方法。最后，围绕环境安全性评价、毒理学机制和新型安全型环境纳米材料的设计等方面，提出并讨论了四个重要的挑战。
Translocation, transfer, and safety evaluation of engineered nanomaterials in non-mammalian alternative assay model of Caenorhabditis elegans are summarized and discussed. Due to the extensive applications of engineered nanomaterials (ENMs) in industry, agriculture, medicine and public health, environmental exposure of ENMs to human and environmental organisms is inevitable, therefore studies on translocation, transfer, and toxicology of ENMs receive wide interest. Modelling the nematode C. elegans, a widely recognized non-mammalian alternative toxicity assay system has been proven to be valuable in environmental safety evaluation, toxicological study, and examination of translocation and transfer of toxicants. In this review, we summarize and discuss the values and contributions of C. elegans in studies on environmental safety evaluation, toxicology, and translocation and transfer of ENMs. We introduced acute and chronic toxicity assay systems and discussed environmental safety assessment of specific ENMs at predicted environmental relevant concentrations, and influences of chemical properties of ENMs, exposure routes, developmental, genetic or physiological state, and environmental factors on nanotoxicity formation in nematodes. We then discussed the toxicological mechanisms of ENMs mainly with respect to roles of oxidative stress in normal and stress conditions and signaling pathways, reproductive toxicology, neurotoxicology, and translocation, distribution, transfer and metabolism of ENMs in C. elegans. Ways to eliminate or reduce the toxicities of specific ENMs by chemical modification with surface designs were further discussed. Finally, four important challenges have been raised and discussed by surrounding the aspects of environmental safety assessment, toxicological mechanisms, and designs of new safe ENMs.